Detailed information NTG0800799

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: P3K50_RS09630
• Genome accession: NZ_CP119715
• Coordinates: 1965884..1966927 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CUVET17-649
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1960884..1971927

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P3K50_RS09600 (P3K50_09580)	-	1961305..1962561 (-)	1257	WP_074347694.1	aminopeptidase	-
P3K50_RS09605 (P3K50_09585)	-	1962564..1962764 (-)	201	WP_000180460.1	DUF1128 family protein	-
P3K50_RS09610 (P3K50_09590)	-	1962911..1963375 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
P3K50_RS09615 (P3K50_09595)	-	1963382..1963657 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
P3K50_RS09620 (P3K50_09600)	-	1963935..1965152 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
P3K50_RS09625 (P3K50_09605)	vraR	1965265..1965894 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
P3K50_RS09630 (P3K50_09610)	vraS	1965884..1966927 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
P3K50_RS09635 (P3K50_09615)	liaF	1966924..1967625 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
P3K50_RS09640 (P3K50_09620)	-	1967640..1968026 (-)	387	WP_001110182.1	hypothetical protein	-
P3K50_RS09645 (P3K50_09625)	map	1968243..1969001 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
P3K50_RS09650 (P3K50_09630)	-	1969585..1970571 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
P3K50_RS09655 (P3K50_09635)	-	1970760..1971173 (-)	414	WP_025174370.1	hypothetical protein	-
P3K50_RS09660 (P3K50_09640)	-	1971202..1971312 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=800799 P3K50_RS09630 WP_001017131.1 1965884..1966927(-) (vraS) [Staphylococcus aureus strain CUVET17-649]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=800799 P3K50_RS09630 WP_001017131.1 1965884..1966927(-) (vraS) [Staphylococcus aureus strain CUVET17-649]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1