Detailed information NTG0800714

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: P3K49_RS09595
• Genome accession: NZ_CP119710
• Coordinates: 1959983..1961026 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CUVET17-1695
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1954983..1966026

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P3K49_RS09565 (P3K49_09545)	-	1955404..1956660 (-)	1257	WP_074347694.1	aminopeptidase	-
P3K49_RS09570 (P3K49_09550)	-	1956663..1956863 (-)	201	WP_000180460.1	DUF1128 family protein	-
P3K49_RS09575 (P3K49_09555)	-	1957010..1957474 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
P3K49_RS09580 (P3K49_09560)	-	1957481..1957756 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
P3K49_RS09585 (P3K49_09565)	-	1958034..1959251 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
P3K49_RS09590 (P3K49_09570)	vraR	1959364..1959993 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
P3K49_RS09595 (P3K49_09575)	vraS	1959983..1961026 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
P3K49_RS09600 (P3K49_09580)	liaF	1961023..1961724 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
P3K49_RS09605 (P3K49_09585)	-	1961739..1962125 (-)	387	WP_001110182.1	hypothetical protein	-
P3K49_RS09610 (P3K49_09590)	map	1962342..1963100 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
P3K49_RS09615 (P3K49_09595)	-	1963684..1964670 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
P3K49_RS09620 (P3K49_09600)	-	1964859..1965272 (-)	414	WP_025174370.1	hypothetical protein	-
P3K49_RS09625 (P3K49_09605)	-	1965301..1965411 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=800714 P3K49_RS09595 WP_001017131.1 1959983..1961026(-) (vraS) [Staphylococcus aureus strain CUVET17-1695]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=800714 P3K49_RS09595 WP_001017131.1 1959983..1961026(-) (vraS) [Staphylococcus aureus strain CUVET17-1695]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1