Detailed information NTG0800296

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: P1X13_RS06245
• Genome accession: NZ_CP119678
• Coordinates: 1260358..1261395 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1004
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1255358..1266395

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P1X13_RS06220 (P1X13_06220)	-	1255362..1255889 (-)	528	WP_002983837.1	Dps family protein	-
P1X13_RS06225 (P1X13_06225)	-	1256117..1256743 (+)	627	WP_002983834.1	A24 family peptidase	-
P1X13_RS06230 (P1X13_06230)	rlmN	1256825..1257904 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
P1X13_RS06235 (P1X13_06235)	-	1257908..1258528 (-)	621	WP_002992791.1	YutD family protein	-
P1X13_RS06240 (P1X13_06240)	-	1258976..1259953 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
P1X13_RS06245 (P1X13_06245)	sepM	1260358..1261395 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
P1X13_RS06250 (P1X13_06250)	coaD	1261382..1261873 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
P1X13_RS06255 (P1X13_06255)	rsmD	1261863..1262402 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
P1X13_RS06260 (P1X13_06260)	asnA	1262525..1263517 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
P1X13_RS06265 (P1X13_06265)	arcC	1263830..1264780 (-)	951	WP_009880962.1	carbamate kinase	-
P1X13_RS06270 (P1X13_06270)	-	1264800..1266131 (-)	1332	WP_136273999.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=800296 P1X13_RS06245 WP_010922499.1 1260358..1261395(-) (sepM) [Streptococcus pyogenes strain 1004]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=800296 P1X13_RS06245 WP_010922499.1 1260358..1261395(-) (sepM) [Streptococcus pyogenes strain 1004]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693