Detailed information NTG0800020

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: P1K34_RS06310
• Genome accession: NZ_CP119598
• Coordinates: 1271839..1272876 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1042
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1266839..1277876

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P1K34_RS06285 (P1K34_06285)	-	1266843..1267370 (-)	528	WP_002983837.1	Dps family protein	-
P1K34_RS06290 (P1K34_06290)	-	1267598..1268224 (+)	627	WP_002983834.1	A24 family peptidase	-
P1K34_RS06295 (P1K34_06295)	rlmN	1268306..1269385 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
P1K34_RS06300 (P1K34_06300)	-	1269389..1270009 (-)	621	WP_002992791.1	YutD family protein	-
P1K34_RS06305 (P1K34_06305)	-	1270457..1271434 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
P1K34_RS06310 (P1K34_06310)	sepM	1271839..1272876 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
P1K34_RS06315 (P1K34_06315)	coaD	1272863..1273354 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
P1K34_RS06320 (P1K34_06320)	rsmD	1273344..1273883 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
P1K34_RS06325 (P1K34_06325)	asnA	1274006..1274998 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
P1K34_RS06330 (P1K34_06330)	arcC	1275311..1276261 (-)	951	WP_009880962.1	carbamate kinase	-
P1K34_RS06335 (P1K34_06335)	-	1276281..1277612 (-)	1332	WP_136273999.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=800020 P1K34_RS06310 WP_010922499.1 1271839..1272876(-) (sepM) [Streptococcus pyogenes strain 1042]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=800020 P1K34_RS06310 WP_010922499.1 1271839..1272876(-) (sepM) [Streptococcus pyogenes strain 1042]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693