Detailed information NTG0799940

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: P1J77_RS01620
• Genome accession: NZ_CP119597
• Coordinates: 336635..337672 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1039
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 331635..342672

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P1J77_RS01595 (P1J77_01595)	-	331899..333230 (+)	1332	WP_136273999.1	dipeptidase	-
P1J77_RS01600 (P1J77_01600)	arcC	333250..334200 (+)	951	WP_009880962.1	carbamate kinase	-
P1J77_RS01605 (P1J77_01605)	asnA	334513..335505 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
P1J77_RS01610 (P1J77_01610)	rsmD	335628..336167 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
P1J77_RS01615 (P1J77_01615)	coaD	336157..336648 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
P1J77_RS01620 (P1J77_01620)	sepM	336635..337672 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
P1J77_RS01625 (P1J77_01625)	-	338077..339054 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
P1J77_RS01630 (P1J77_01630)	-	339502..340122 (+)	621	WP_002992791.1	YutD family protein	-
P1J77_RS01635 (P1J77_01635)	rlmN	340126..341205 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
P1J77_RS01640 (P1J77_01640)	-	341287..341913 (-)	627	WP_002983834.1	A24 family peptidase	-
P1J77_RS01645 (P1J77_01645)	-	342141..342668 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=799940 P1J77_RS01620 WP_010922499.1 336635..337672(+) (sepM) [Streptococcus pyogenes strain 1039]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=799940 P1J77_RS01620 WP_010922499.1 336635..337672(+) (sepM) [Streptococcus pyogenes strain 1039]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693