Detailed information NTG0798654

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: P1A15_RS10000
• Genome accession: NZ_CP119340
• Coordinates: 2026694..2027737 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain N28CSA05
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2021694..2032737

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P1A15_RS09970 (P1A15_09970)	-	2022116..2023372 (-)	1257	WP_001789555.1	aminopeptidase	-
P1A15_RS09975 (P1A15_09975)	-	2023375..2023575 (-)	201	WP_000180460.1	DUF1128 family protein	-
P1A15_RS09980 (P1A15_09980)	-	2023722..2024186 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
P1A15_RS09985 (P1A15_09985)	-	2024193..2024468 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
P1A15_RS09990 (P1A15_09990)	-	2024746..2025963 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
P1A15_RS09995 (P1A15_09995)	vraR	2026075..2026704 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
P1A15_RS10000 (P1A15_10000)	vraS	2026694..2027737 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
P1A15_RS10005 (P1A15_10005)	liaF	2027734..2028435 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
P1A15_RS10010 (P1A15_10010)	-	2028450..2028836 (-)	387	WP_001110179.1	hypothetical protein	-
P1A15_RS10015 (P1A15_10015)	map	2029053..2029811 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
P1A15_RS10020 (P1A15_10020)	-	2030223..2031209 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
P1A15_RS10025 (P1A15_10025)	-	2031640..2032053 (-)	414	WP_001670387.1	hypothetical protein	-
P1A15_RS10030 (P1A15_10030)	-	2032082..2032192 (-)	111	WP_031775032.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=798654 P1A15_RS10000 WP_001017131.1 2026694..2027737(-) (vraS) [Staphylococcus aureus strain N28CSA05]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=798654 P1A15_RS10000 WP_001017131.1 2026694..2027737(-) (vraS) [Staphylococcus aureus strain N28CSA05]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1