Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   P1A14_RS00165 Genome accession   NZ_CP119338
Coordinates   43082..44431 (-) Length   449 a.a.
NCBI ID   WP_275593721.1    Uniprot ID   -
Organism   Staphylococcus aureus strain N09HSA11     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 43087..88324 43082..44431 flank -1344


Gene organization within MGE regions


Location: 43082..88324
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P1A14_RS00165 (P1A14_00165) ccrA 43082..44431 (-) 1350 WP_275593721.1 recombinase family protein Machinery gene
  P1A14_RS00170 (P1A14_00170) - 44622..44900 (-) 279 WP_084944755.1 hypothetical protein -
  P1A14_RS00175 (P1A14_00175) - 44970..46769 (-) 1800 WP_275593722.1 DUF927 domain-containing protein -
  P1A14_RS00180 (P1A14_00180) - 46897..48324 (-) 1428 WP_275593723.1 DUF6038 family protein -
  P1A14_RS00185 (P1A14_00185) - 48541..49704 (+) 1164 WP_069854462.1 ATP-binding protein -
  P1A14_RS00190 (P1A14_00190) - 49717..50517 (+) 801 WP_069854463.1 abortive infection family protein -
  P1A14_RS00195 (P1A14_00195) - 51195..51584 (+) 390 WP_049948298.1 DUF6339 family protein -
  P1A14_RS00200 (P1A14_00200) - 51679..51957 (+) 279 WP_224103024.1 DUF2975 domain-containing protein -
  P1A14_RS00205 (P1A14_00205) - 51968..52171 (+) 204 WP_209307420.1 helix-turn-helix transcriptional regulator -
  P1A14_RS00210 (P1A14_00210) - 52520..53623 (+) 1104 WP_053865759.1 DUF418 domain-containing protein -
  P1A14_RS00215 (P1A14_00215) - 53649..54371 (+) 723 WP_031775117.1 CPBP family intramembrane glutamic endopeptidase -
  P1A14_RS00220 (P1A14_00220) - 54571..55665 (+) 1095 WP_031590773.1 IS30 family transposase -
  P1A14_RS00225 (P1A14_00225) - 56474..58075 (+) 1602 Protein_42 L-lactate permease -
  P1A14_RS00230 (P1A14_00230) - 58261..58662 (+) 402 WP_049948297.1 hypothetical protein -
  P1A14_RS00235 (P1A14_00235) - 58826..59209 (-) 384 WP_078098742.1 DDE-type integrase/transposase/recombinase -
  P1A14_RS00240 (P1A14_00240) - 59193..59414 (-) 222 WP_078098741.1 IS3 family transposase -
  P1A14_RS00245 (P1A14_00245) - 59516..59956 (-) 441 WP_031590800.1 HTH domain-containing protein -
  P1A14_RS00250 (P1A14_00250) - 60123..60860 (-) 738 Protein_47 GntR family transcriptional regulator -
  P1A14_RS00255 (P1A14_00255) - 61244..62338 (-) 1095 WP_031590773.1 IS30 family transposase -
  P1A14_RS00260 (P1A14_00260) - 62538..63260 (-) 723 WP_031775117.1 CPBP family intramembrane glutamic endopeptidase -
  P1A14_RS00265 (P1A14_00265) - 63286..64389 (-) 1104 WP_053865759.1 DUF418 domain-containing protein -
  P1A14_RS00270 (P1A14_00270) - 64738..64941 (-) 204 WP_209307420.1 helix-turn-helix transcriptional regulator -
  P1A14_RS00275 (P1A14_00275) - 64952..65230 (-) 279 WP_224103024.1 DUF2975 domain-containing protein -
  P1A14_RS00280 (P1A14_00280) - 65325..65714 (-) 390 WP_049948298.1 DUF6339 family protein -
  P1A14_RS00285 (P1A14_00285) - 65773..66624 (-) 852 Protein_54 recombinase family protein -
  P1A14_RS00290 (P1A14_00290) - 66802..67059 (-) 258 WP_002434121.1 hypothetical protein -
  P1A14_RS00295 (P1A14_00295) - 67127..68917 (-) 1791 WP_031590847.1 DUF927 domain-containing protein -
  P1A14_RS00300 (P1A14_00300) - 69043..70470 (-) 1428 WP_031590850.1 DUF6038 family protein -
  P1A14_RS00305 (P1A14_00305) - 70587..71351 (+) 765 WP_031590857.1 DUF6414 family protein -
  P1A14_RS00310 (P1A14_00310) - 71341..72456 (+) 1116 WP_031590860.1 AAA family ATPase -
  P1A14_RS00315 (P1A14_00315) - 72618..73841 (+) 1224 WP_050438896.1 hypothetical protein -
  P1A14_RS00320 (P1A14_00320) - 74406..74681 (+) 276 WP_231385368.1 GNAT family N-acetyltransferase -
  P1A14_RS00325 (P1A14_00325) - 74963..75883 (+) 921 WP_224684921.1 SEFIR domain-containing protein -
  P1A14_RS00330 (P1A14_00330) - 75955..77415 (+) 1461 WP_031590866.1 DUF6038 family protein -
  P1A14_RS00335 (P1A14_00335) - 77617..78693 (+) 1077 WP_031590869.1 DNA polymerase -
  P1A14_RS00340 (P1A14_00340) - 78710..79084 (+) 375 WP_031590871.1 hypothetical protein -
  P1A14_RS00345 (P1A14_00345) - 79077..80690 (+) 1614 WP_031590872.1 DUF5906 domain-containing protein -
  P1A14_RS00350 (P1A14_00350) - 80779..80910 (+) 132 WP_256769442.1 hypothetical protein -
  P1A14_RS00355 (P1A14_00355) - 80917..82602 (+) 1686 WP_031590875.1 recombinase family protein -
  P1A14_RS00360 (P1A14_00360) - 82691..83029 (+) 339 WP_031775842.1 SAUGI family uracil-DNA glycosylase inhibitor -
  P1A14_RS00365 (P1A14_00365) - 83122..83433 (+) 312 WP_031590878.1 DUF960 family protein -
  P1A14_RS00370 (P1A14_00370) - 83449..83952 (+) 504 WP_031590880.1 DUF1643 domain-containing protein -
  P1A14_RS00375 (P1A14_00375) - 83966..84187 (+) 222 WP_031590882.1 hypothetical protein -
  P1A14_RS00380 (P1A14_00380) - 84372..85115 (+) 744 WP_031590884.1 hypothetical protein -
  P1A14_RS00385 (P1A14_00385) - 85396..86070 (-) 675 WP_001105994.1 IS6-like element IS257 family transposase -
  P1A14_RS00390 (P1A14_00390) - 86111..86218 (-) 108 Protein_75 beta-lactam sensor/signal transducer MecR1 -
  P1A14_RS00395 (P1A14_00395) mecA 86315..88324 (+) 2010 WP_078098983.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52456.17 Da        Isoelectric Point: 9.9280

>NTDB_id=798579 P1A14_RS00165 WP_275593721.1 43082..44431(-) (ccrA) [Staphylococcus aureus strain N09HSA11]
MKQAIGYLRQSTTKQQSLSAQKQTIKALAEKHNIQHITFYSDKQSGRTENRTGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKMITTHALFGYHYH
NGTFTIDTVKAPTIKAVFNYYLQGYGYKKIAQYLEADNKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVIRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKTDHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLAI
CQDFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQQSKPISSISAYQIRKAFQ
NIIQQRFTLNMLYPYIDEIHITKNKALVGIYFKNEPLNIVNQTSQSSIV

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=798579 P1A14_RS00165 WP_275593721.1 43082..44431(-) (ccrA) [Staphylococcus aureus strain N09HSA11]
ATGAAACAAGCAATAGGTTACTTACGACAGAGCACTACAAAGCAACAATCACTCTCGGCTCAGAAACAAACCATCAAAGC
ATTAGCCGAAAAGCATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGTAGAACTGAAAATCGAACAGGCT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATGTGACGTATTATGTTGCTATCGTCTGAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAACTCATGAAATTATGTCAAAAATACCATGTTCATATCTTAAGCGTTCATGATGGCTATTTTGA
TATGGATAAAGCATTCGATCGGCTTAAACTTAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAAATGATTACAACACATGCACTCTTTGGGTATCACTATCAT
AATGGTACTTTCACAATAGACACAGTAAAAGCACCAACAATAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATAATAAATTCATTAATCGCAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTATCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAAACAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAATGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGATT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAATCAAAACCTATATCATCAATCAGTGCGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTCACATTACTAAAAACAAAGCCCT
TGTTGGGATTTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGTCTAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(170-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-319)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

92.873

100

0.929
  ccrA Staphylococcus aureus N315

74.833

100

0.748