Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | PXV46_RS00430 | Genome accession | NZ_CP119113 |
| Coordinates | 90381..92009 (-) | Length | 542 a.a. |
| NCBI ID | WP_071562990.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain GENOMIC22-002 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 41069..97795 | 90381..92009 | within | 0 |
Gene organization within MGE regions
Location: 41069..97795
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PXV46_RS00165 (PXV46_00165) | - | 41069..42745 (+) | 1677 | WP_000676596.1 | recombinase family protein | - |
| PXV46_RS00170 (PXV46_00170) | - | 42851..43189 (+) | 339 | WP_000171559.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| PXV46_RS00175 (PXV46_00175) | - | 43285..43596 (+) | 312 | WP_001083109.1 | DUF960 family protein | - |
| PXV46_RS00180 (PXV46_00180) | - | 43612..44118 (+) | 507 | WP_000447786.1 | DUF1643 domain-containing protein | - |
| PXV46_RS00185 (PXV46_00185) | - | 44267..44941 (-) | 675 | WP_001106056.1 | IS6-like element IS257 family transposase | - |
| PXV46_RS00190 (PXV46_00190) | - | 45025..45366 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| PXV46_RS00195 (PXV46_00195) | - | 46283..47026 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| PXV46_RS00200 (PXV46_00200) | - | 47123..47551 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| PXV46_RS00205 (PXV46_00205) | mecA | 47597..49606 (-) | 2010 | WP_078099308.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| PXV46_RS00210 (PXV46_00210) | - | 49703..49810 (+) | 108 | Protein_39 | beta-lactam sensor/signal transducer MecR1 | - |
| PXV46_RS00215 (PXV46_00215) | - | 49851..50525 (+) | 675 | Protein_40 | IS6 family transposase | - |
| PXV46_RS00220 (PXV46_00220) | - | 50585..51013 (-) | 429 | WP_000671996.1 | VOC family protein | - |
| PXV46_RS00225 (PXV46_00225) | - | 51094..52023 (+) | 930 | WP_000750311.1 | HTH domain-containing protein | - |
| PXV46_RS00230 (PXV46_00230) | - | 52185..54173 (+) | 1989 | WP_001038847.1 | hypothetical protein | - |
| PXV46_RS00235 (PXV46_00235) | - | 54368..55477 (+) | 1110 | WP_000283873.1 | DNA polymerase | - |
| PXV46_RS00240 (PXV46_00240) | - | 55470..55838 (+) | 369 | WP_001058155.1 | hypothetical protein | - |
| PXV46_RS00245 (PXV46_00245) | - | 55838..57454 (+) | 1617 | WP_001015575.1 | DUF5906 domain-containing protein | - |
| PXV46_RS00250 (PXV46_00250) | - | 57679..59358 (+) | 1680 | WP_000676595.1 | recombinase family protein | - |
| PXV46_RS00255 (PXV46_00255) | - | 59447..59785 (+) | 339 | WP_000175890.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| PXV46_RS00260 (PXV46_00260) | - | 59879..60190 (+) | 312 | WP_001024802.1 | DUF960 domain-containing protein | - |
| PXV46_RS00265 (PXV46_00265) | - | 60205..60675 (+) | 471 | WP_001092192.1 | DUF1643 domain-containing protein | - |
| PXV46_RS00270 (PXV46_00270) | - | 60716..61390 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| PXV46_RS00275 (PXV46_00275) | tet(K) | 61587..62966 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| PXV46_RS00280 (PXV46_00280) | mobV | 63152..64393 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| PXV46_RS00285 (PXV46_00285) | - | 64920..65874 (+) | 955 | Protein_54 | replication initiation factor domain-containing protein | - |
| PXV46_RS00290 (PXV46_00290) | - | 65962..66636 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| PXV46_RS14580 | - | 66911..67309 (+) | 399 | WP_000145226.1 | DNA topoisomerase | - |
| PXV46_RS00300 (PXV46_00300) | - | 67351..67653 (+) | 303 | WP_223223648.1 | HNH endonuclease | - |
| PXV46_RS00305 (PXV46_00305) | - | 67586..68215 (-) | 630 | Protein_58 | hypothetical protein | - |
| PXV46_RS00310 (PXV46_00310) | - | 68224..68562 (+) | 339 | Protein_59 | recombinase family protein | - |
| PXV46_RS00315 (PXV46_00315) | - | 68674..69033 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| PXV46_RS00320 (PXV46_00320) | - | 69240..69566 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| PXV46_RS00325 (PXV46_00325) | - | 69896..71821 (+) | 1926 | WP_000790094.1 | heavy metal translocating P-type ATPase | - |
| PXV46_RS00330 (PXV46_00330) | cstB | 72967..74295 (-) | 1329 | WP_016187232.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| PXV46_RS00335 (PXV46_00335) | - | 74314..75381 (-) | 1068 | WP_000085030.1 | DsrE/DsrF/DrsH-like family protein | - |
| PXV46_RS00340 (PXV46_00340) | cstR | 75520..75780 (+) | 261 | WP_000456195.1 | persulfide-sensing transcriptional repressor CstR | - |
| PXV46_RS00345 (PXV46_00345) | - | 75777..76535 (+) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| PXV46_RS00350 (PXV46_00350) | - | 76705..76914 (+) | 210 | Protein_67 | heavy metal translocating P-type ATPase | - |
| PXV46_RS00355 (PXV46_00355) | - | 76932..77477 (+) | 546 | WP_000592151.1 | YdhK family protein | - |
| PXV46_RS00360 (PXV46_00360) | - | 77758..79545 (+) | 1788 | WP_275276429.1 | DUF4209 domain-containing protein | - |
| PXV46_RS00365 (PXV46_00365) | - | 79586..80281 (+) | 696 | WP_275276430.1 | hypothetical protein | - |
| PXV46_RS00370 (PXV46_00370) | - | 80364..80741 (+) | 378 | WP_275276431.1 | hypothetical protein | - |
| PXV46_RS00375 (PXV46_00375) | - | 81162..83954 (+) | 2793 | WP_070657165.1 | type I restriction endonuclease subunit R | - |
| PXV46_RS00380 (PXV46_00380) | - | 84044..84625 (+) | 582 | WP_070657162.1 | restriction endonuclease subunit S | - |
| PXV46_RS00385 (PXV46_00385) | - | 84626..86182 (+) | 1557 | WP_070657159.1 | type I restriction-modification system subunit M | - |
| PXV46_RS00390 (PXV46_00390) | - | 86175..86798 (+) | 624 | WP_275276432.1 | restriction endonuclease subunit S | - |
| PXV46_RS00395 (PXV46_00395) | - | 86771..87421 (+) | 651 | WP_275276433.1 | restriction endonuclease subunit S | - |
| PXV46_RS00400 (PXV46_00400) | - | 87467..87850 (+) | 384 | WP_070657153.1 | hypothetical protein | - |
| PXV46_RS00405 (PXV46_00405) | - | 88002..88223 (-) | 222 | Protein_78 | hypothetical protein | - |
| PXV46_RS00410 (PXV46_00410) | - | 88238..88744 (-) | 507 | WP_119627602.1 | DUF1643 domain-containing protein | - |
| PXV46_RS00415 (PXV46_00415) | - | 88758..89069 (-) | 312 | WP_057510703.1 | DUF960 family protein | - |
| PXV46_RS00420 (PXV46_00420) | - | 89165..89503 (-) | 339 | WP_053464901.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| PXV46_RS00425 (PXV46_00425) | - | 90058..90345 (+) | 288 | WP_103266532.1 | hypothetical protein | - |
| PXV46_RS00430 (PXV46_00430) | ccrB | 90381..92009 (-) | 1629 | WP_071562990.1 | recombinase family protein | Machinery gene |
| PXV46_RS00435 (PXV46_00435) | ccrA | 92029..93378 (-) | 1350 | WP_070657147.1 | recombinase family protein | Machinery gene |
| PXV46_RS00440 (PXV46_00440) | - | 93578..94216 (-) | 639 | Protein_85 | hypothetical protein | - |
| PXV46_RS00445 (PXV46_00445) | - | 94225..94563 (+) | 339 | Protein_86 | recombinase family protein | - |
| PXV46_RS00450 (PXV46_00450) | - | 94675..95034 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| PXV46_RS00455 (PXV46_00455) | - | 95241..95567 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| PXV46_RS00460 (PXV46_00460) | - | 95870..97795 (+) | 1926 | WP_070657144.1 | heavy metal translocating P-type ATPase | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62506.39 Da Isoelectric Point: 9.7287
>NTDB_id=797716 PXV46_RS00430 WP_071562990.1 90381..92009(-) (ccrB) [Staphylococcus aureus strain GENOMIC22-002]
MQQLKQKRVGIYVRVSTEMQSAEGYSIDGQINQIKEYCNFHHFEVKDIYADRGISGKSMNRPELQRMLKDANEGHIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKMANALNHKGYVTKKGNPFNTSAIAYILSNPFYIGKIQFAK
YKDWNEKRRKGLNDNPVVADGKHSPIISQELWDKVHSRMKQVSQKPQVHGKGTNILTGLISCPKCSASMSASTTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVIKQVVERVNQENRVDVAALNHDIAYKQQQFD
EINTKLKNLVQTIEDNPDLTSALKPTIHQYETQLNDITNQMNQLKQQQNQEKPSYDTKQIALLLQRIFQNIESMDKSQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTQLDEVLLSTSSLFLPQTLYLKI
MQQLKQKRVGIYVRVSTEMQSAEGYSIDGQINQIKEYCNFHHFEVKDIYADRGISGKSMNRPELQRMLKDANEGHIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKMANALNHKGYVTKKGNPFNTSAIAYILSNPFYIGKIQFAK
YKDWNEKRRKGLNDNPVVADGKHSPIISQELWDKVHSRMKQVSQKPQVHGKGTNILTGLISCPKCSASMSASTTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVIKQVVERVNQENRVDVAALNHDIAYKQQQFD
EINTKLKNLVQTIEDNPDLTSALKPTIHQYETQLNDITNQMNQLKQQQNQEKPSYDTKQIALLLQRIFQNIESMDKSQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTQLDEVLLSTSSLFLPQTLYLKI
Nucleotide
Download Length: 1629 bp
>NTDB_id=797716 PXV46_RS00430 WP_071562990.1 90381..92009(-) (ccrB) [Staphylococcus aureus strain GENOMIC22-002]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTCCGCGTATCAACAGAAATGCAAAGTGCAGAGGGTTATAGTAT
CGATGGGCAAATCAATCAAATCAAAGAATATTGTAACTTCCATCATTTCGAAGTCAAAGATATATACGCTGATCGTGGTA
TTTCAGGAAAATCTATGAACCGCCCTGAGCTCCAACGTATGTTGAAGGATGCGAATGAAGGTCATATCGATTGTGTCATG
GTGTATAAAACAAACCGACTTGCACGTAATACATCAGACTTGCTCAAAATTGTCGAGGATTTGCATAAACAGAACGTCGA
ATTTTTCAGTTTGTCTGAACGTATGGAAGTCAACACTTCTTCGGGTAAACTCATGTTACAAATACTCGCAAGCTTCTCTG
AATTCGAACGCAATAACATTGTAGAAAATGTCTTCATGGGTCAAACCAGACGTGCACAAGAAGGCTATTATCAAGGGAAT
TTACCACTAGGATATGATAAAATACCTGATAGTAAGCATGAACTCATGATAAACCAACATGAAGCCAATATTGTAAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATGGCTAATGCACTTAATCATAAAGGTTATGTAACAAAGA
AAGGTAATCCATTCAATACATCAGCTATAGCATACATCCTTTCCAATCCTTTTTACATTGGTAAAATACAATTTGCGAAA
TATAAAGATTGGAATGAAAAGCGACGTAAAGGCCTTAATGATAATCCTGTAGTAGCTGACGGGAAGCATTCGCCTATCAT
TAGTCAAGAACTATGGGATAAAGTACATTCACGTATGAAACAAGTTAGTCAAAAACCACAAGTTCATGGTAAAGGGACAA
ATATTTTAACTGGGTTAATTTCGTGTCCAAAATGTTCTGCTTCTATGTCTGCGAGCACGACAACCAATACACTTAAAGAT
GGTACAAAAAAGCGAATACGCTATTATTCCTGTAGTAATTTTCGCAACAAAGGATCGAAAGTGTGTTCTGCAAATAGTGT
TAGAGCTGATGTTATCGAAAAGTATGTTATGGATCAAATACTCGAAATAGTCAAAAGTGATAAAGTTATCAAACAAGTTG
TCGAACGTGTCAATCAAGAGAATAGAGTCGATGTAGCTGCGCTCAATCATGATATTGCTTATAAACAACAACAATTTGAT
GAAATTAACACTAAACTTAAAAATCTAGTTCAAACCATCGAAGACAATCCAGACTTAACATCTGCACTCAAACCAACCAT
TCATCAATATGAAACACAACTCAATGACATTACAAACCAAATGAATCAACTAAAGCAGCAACAAAATCAAGAGAAACCAT
CTTATGATACGAAACAAATCGCTCTCCTATTACAACGAATATTTCAAAACATAGAATCCATGGATAAATCACAACTCAAA
GCATTATACCTTACGGTCATTGATCGTATCGATATTCGTAAAGATGGGAATCATAAAAAGCAATTCTATGTCACACTCAA
GCTCAATAATGAGATTATTAAACAACTTTTCAATAATACTCAGCTCGACGAAGTGCTTCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACTCTTTACCTTAAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTCCGCGTATCAACAGAAATGCAAAGTGCAGAGGGTTATAGTAT
CGATGGGCAAATCAATCAAATCAAAGAATATTGTAACTTCCATCATTTCGAAGTCAAAGATATATACGCTGATCGTGGTA
TTTCAGGAAAATCTATGAACCGCCCTGAGCTCCAACGTATGTTGAAGGATGCGAATGAAGGTCATATCGATTGTGTCATG
GTGTATAAAACAAACCGACTTGCACGTAATACATCAGACTTGCTCAAAATTGTCGAGGATTTGCATAAACAGAACGTCGA
ATTTTTCAGTTTGTCTGAACGTATGGAAGTCAACACTTCTTCGGGTAAACTCATGTTACAAATACTCGCAAGCTTCTCTG
AATTCGAACGCAATAACATTGTAGAAAATGTCTTCATGGGTCAAACCAGACGTGCACAAGAAGGCTATTATCAAGGGAAT
TTACCACTAGGATATGATAAAATACCTGATAGTAAGCATGAACTCATGATAAACCAACATGAAGCCAATATTGTAAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATGGCTAATGCACTTAATCATAAAGGTTATGTAACAAAGA
AAGGTAATCCATTCAATACATCAGCTATAGCATACATCCTTTCCAATCCTTTTTACATTGGTAAAATACAATTTGCGAAA
TATAAAGATTGGAATGAAAAGCGACGTAAAGGCCTTAATGATAATCCTGTAGTAGCTGACGGGAAGCATTCGCCTATCAT
TAGTCAAGAACTATGGGATAAAGTACATTCACGTATGAAACAAGTTAGTCAAAAACCACAAGTTCATGGTAAAGGGACAA
ATATTTTAACTGGGTTAATTTCGTGTCCAAAATGTTCTGCTTCTATGTCTGCGAGCACGACAACCAATACACTTAAAGAT
GGTACAAAAAAGCGAATACGCTATTATTCCTGTAGTAATTTTCGCAACAAAGGATCGAAAGTGTGTTCTGCAAATAGTGT
TAGAGCTGATGTTATCGAAAAGTATGTTATGGATCAAATACTCGAAATAGTCAAAAGTGATAAAGTTATCAAACAAGTTG
TCGAACGTGTCAATCAAGAGAATAGAGTCGATGTAGCTGCGCTCAATCATGATATTGCTTATAAACAACAACAATTTGAT
GAAATTAACACTAAACTTAAAAATCTAGTTCAAACCATCGAAGACAATCCAGACTTAACATCTGCACTCAAACCAACCAT
TCATCAATATGAAACACAACTCAATGACATTACAAACCAAATGAATCAACTAAAGCAGCAACAAAATCAAGAGAAACCAT
CTTATGATACGAAACAAATCGCTCTCCTATTACAACGAATATTTCAAAACATAGAATCCATGGATAAATCACAACTCAAA
GCATTATACCTTACGGTCATTGATCGTATCGATATTCGTAAAGATGGGAATCATAAAAAGCAATTCTATGTCACACTCAA
GCTCAATAATGAGATTATTAAACAACTTTTCAATAATACTCAGCTCGACGAAGTGCTTCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACTCTTTACCTTAAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
85.793 |
100 |
0.858 |