Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   PYH74_RS00170 Genome accession   NZ_CP118814
Coordinates   42511..43872 (-) Length   453 a.a.
NCBI ID   WP_061544228.1    Uniprot ID   -
Organism   Staphylococcus epidermidis strain 7060     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 41185..57183 42511..43872 within 0


Gene organization within MGE regions


Location: 41185..57183
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PYH74_RS00170 (PYH74_00170) ccrA 42511..43872 (-) 1362 WP_061544228.1 recombinase family protein Machinery gene
  PYH74_RS00175 (PYH74_00175) - 44083..45849 (-) 1767 WP_061544227.1 DUF927 domain-containing protein -
  PYH74_RS00180 (PYH74_00180) - 45849..46142 (-) 294 WP_046464617.1 hypothetical protein -
  PYH74_RS00185 (PYH74_00185) - 46313..47827 (-) 1515 WP_046464618.1 hypothetical protein -
  PYH74_RS00190 (PYH74_00190) - 48458..49369 (+) 912 WP_046464619.1 ABC transporter substrate-binding protein -
  PYH74_RS00195 (PYH74_00195) - 49402..49572 (-) 171 WP_155734542.1 hypothetical protein -
  PYH74_RS00200 (PYH74_00200) - 49619..50293 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  PYH74_RS00205 (PYH74_00205) - 50377..50718 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  PYH74_RS00210 (PYH74_00210) - 51635..52378 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  PYH74_RS00215 (PYH74_00215) - 52475..52903 (+) 429 WP_000872606.1 MaoC family dehydratase -
  PYH74_RS00220 (PYH74_00220) mecA 52949..54958 (-) 2010 WP_103298748.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  PYH74_RS00225 (PYH74_00225) mecR1 55055..56812 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  PYH74_RS00230 (PYH74_00230) mecI 56812..57183 (+) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 52936.78 Da        Isoelectric Point: 9.8297

>NTDB_id=795518 PYH74_RS00170 WP_061544228.1 42511..43872(-) (ccrA) [Staphylococcus epidermidis strain 7060]
MEKAIAYVRQSTLKQQSLATQKSLIIDTAKQHGWSNVTFYDDKKTGGHTKRSGYQKMVEVITSGECKVLCCYRLNRLHRN
FKNAIQFFEICKKHHVTIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTRNGIREKAKQGKLITTHAPFGYHYS
KGHFIVNAEEAPTIKAVYRWYLQGLGYKKISQKLDKDMNFISRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIINVDT
FEEAQERRIHKQHNRSNSRNKLKRRIKCPYCQSTLTNLTIKKEHRSLRYYVCPKNMNEAYHTCPFKGINAQMIETEVLNT
CKVYCGNQSFHDKLNETILKALKHQQMKHRQSHLTQEQLIEKLAQNQIDIETFKRLSAGFEREERYSNYSSNQIAETIRH
VVKDKLTLEIIAPLIDDITITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=795518 PYH74_RS00170 WP_061544228.1 42511..43872(-) (ccrA) [Staphylococcus epidermidis strain 7060]
ATGGAAAAAGCCATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCGACTCAGAAATCCCTCATTATAGA
CACTGCTAAGCAACATGGATGGTCCAATGTAACATTTTATGATGATAAAAAAACAGGTGGACATACAAAGCGTTCAGGCT
ATCAAAAAATGGTAGAAGTGATTACATCTGGAGAGTGTAAAGTATTATGTTGCTATCGGCTAAATCGGCTCCATCGTAAT
TTCAAAAATGCTATACAATTCTTTGAAATTTGTAAAAAGCATCACGTCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGCTTAAACATACTCATGAGTCTAGCAGAAATGGAATCGAACAACATCAGCGAAC
AAACACGAAATGGGATAAGAGAAAAAGCCAAACAAGGTAAGTTGATTACAACACACGCCCCTTTTGGTTATCACTACAGC
AAAGGTCACTTTATTGTAAATGCAGAAGAAGCACCGACAATCAAAGCCGTTTATCGTTGGTATTTACAAGGACTTGGTTA
CAAGAAAATTTCTCAAAAGCTGGATAAAGATATGAATTTTATTTCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGTGGTCGTGTCATTAATAAATATGGAACGTTTAATGATATCGTTCCACCTATTATTAATGTTGATACG
TTTGAGGAAGCACAAGAGCGTCGTATTCATAAACAACACAATCGATCCAATTCTAGAAATAAGTTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAACATCGTTCTCTACGTTACTATGTCTGTCCTA
AAAATATGAATGAAGCCTATCATACGTGTCCATTTAAAGGCATCAATGCGCAAATGATTGAAACAGAGGTCCTAAACACT
TGTAAAGTATACTGTGGCAATCAATCATTTCATGACAAATTAAATGAGACAATACTAAAAGCTCTAAAACACCAACAAAT
GAAACACAGACAATCACATCTAACACAAGAACAACTCATCGAAAAACTAGCACAAAATCAAATTGATATAGAAACATTTA
AACGGTTATCTGCTGGCTTTGAAAGAGAAGAACGTTACTCTAATTATTCATCCAATCAAATTGCTGAAACAATCCGTCAT
GTAGTCAAAGATAAATTGACATTAGAAATCATAGCACCTTTGATTGATGACATTACAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCGCATTTAATAACTCCTGAAAGGAATGAAGTCATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

55.305

97.792

0.541
  ccrA Staphylococcus aureus N315

52.37

97.792

0.512