Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   PW220_RS09215 Genome accession   NZ_CP118734
Coordinates   1846146..1848602 (-) Length   818 a.a.
NCBI ID   WP_248055567.1    Uniprot ID   A0AA97A2L9
Organism   Streptococcus iners subsp. hyiners strain 29892     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1844459..1872908 1846146..1848602 within 0


Gene organization within MGE regions


Location: 1844459..1872908
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PW220_RS09205 (PW220_09210) dusB 1844459..1845463 (+) 1005 WP_248055565.1 tRNA dihydrouridine synthase DusB -
  PW220_RS09210 (PW220_09215) - 1845560..1846051 (-) 492 WP_248055566.1 adenylyltransferase/cytidyltransferase family protein -
  PW220_RS09215 (PW220_09220) clpC 1846146..1848602 (-) 2457 WP_248055567.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  PW220_RS09220 (PW220_09225) - 1848607..1849065 (-) 459 WP_248055571.1 CtsR family transcriptional regulator -
  PW220_RS09225 (PW220_09230) - 1849345..1849683 (+) 339 WP_172090909.1 thioredoxin domain-containing protein -
  PW220_RS09230 (PW220_09235) - 1849683..1850384 (+) 702 WP_248055572.1 GNAT family acetyltransferase -
  PW220_RS09235 (PW220_09240) tsf 1850540..1851580 (-) 1041 WP_099806551.1 translation elongation factor Ts -
  PW220_RS09240 (PW220_09245) rpsB 1851736..1852512 (-) 777 WP_014637198.1 30S ribosomal protein S2 -
  PW220_RS09245 (PW220_09250) - 1852698..1853690 (-) 993 WP_248055574.1 DUF4767 domain-containing protein -
  PW220_RS09250 (PW220_09255) - 1853710..1854861 (-) 1152 WP_248055576.1 DUF6287 domain-containing protein -
  PW220_RS09260 (PW220_09265) nusG 1855286..1855825 (-) 540 WP_002940254.1 transcription termination/antitermination protein NusG -
  PW220_RS09265 (PW220_09270) secE 1855935..1856111 (-) 177 WP_248055578.1 preprotein translocase subunit SecE -
  PW220_RS09270 (PW220_09275) rpmG 1856121..1856273 (-) 153 WP_002940258.1 50S ribosomal protein L33 -
  PW220_RS09275 (PW220_09280) pbp2a 1856307..1858526 (-) 2220 WP_248055582.1 penicillin-binding protein PBP2A -
  PW220_RS09280 (PW220_09285) - 1858679..1859647 (+) 969 WP_248055584.1 NAD(P)/FAD-dependent oxidoreductase -
  PW220_RS09285 (PW220_09290) - 1859649..1860518 (+) 870 WP_248055586.1 RluA family pseudouridine synthase -
  PW220_RS09290 (PW220_09295) - 1860568..1860876 (-) 309 Protein_1802 type VII secretion protein EssC -
  PW220_RS09295 (PW220_09300) - 1861304..1861603 (-) 300 WP_248055588.1 DUF4176 domain-containing protein -
  PW220_RS09300 (PW220_09305) - 1861618..1862220 (-) 603 WP_248055590.1 DUF443 family protein -
  PW220_RS09305 (PW220_09310) - 1862239..1862871 (-) 633 WP_248055591.1 DUF443 family protein -
  PW220_RS09310 (PW220_09315) - 1863102..1863728 (-) 627 WP_248055593.1 DUF443 family protein -
  PW220_RS09315 (PW220_09320) - 1863716..1865185 (-) 1470 WP_248055595.1 T7SS effector LXG polymorphic toxin -
  PW220_RS09320 (PW220_09325) - 1865178..1865351 (-) 174 WP_248055597.1 hypothetical protein -
  PW220_RS09325 (PW220_09330) - 1865501..1865803 (-) 303 WP_248055600.1 DUF4176 domain-containing protein -
  PW220_RS09330 (PW220_09335) - 1865840..1866496 (-) 657 WP_248055602.1 DUF443 family protein -
  PW220_RS09335 (PW220_09340) - 1866693..1867349 (-) 657 WP_248055604.1 hypothetical protein -
  PW220_RS09340 (PW220_09345) - 1867604..1867741 (-) 138 WP_248055608.1 DUF4176 domain-containing protein -
  PW220_RS09345 (PW220_09350) - 1867753..1868409 (-) 657 WP_248055611.1 hypothetical protein -
  PW220_RS09350 (PW220_09355) - 1868629..1869420 (-) 792 WP_105210102.1 hypothetical protein -
  PW220_RS09355 (PW220_09360) - 1869423..1869704 (-) 282 WP_316716470.1 DUF4176 domain-containing protein -
  PW220_RS09360 (PW220_09365) - 1869722..1870552 (-) 831 WP_029743644.1 hypothetical protein -
  PW220_RS09365 (PW220_09370) - 1870641..1871486 (-) 846 WP_248055617.1 hypothetical protein -
  PW220_RS10380 - 1871598..1871807 (-) 210 WP_398582938.1 YwqH-like family protein -
  PW220_RS09370 (PW220_09375) - 1871853..1872365 (-) 513 WP_248055621.1 DUF3592 domain-containing protein -
  PW220_RS09375 (PW220_09380) - 1872369..1872908 (-) 540 WP_248055623.1 hypothetical protein -

Sequence

Protein


Download         Length: 818 a.a.        Molecular weight: 90498.16 Da        Isoelectric Point: 6.7154

>NTDB_id=794704 PW220_RS09215 WP_248055567.1 1846146..1848602(-) (clpC) [Streptococcus iners subsp. hyiners strain 29892]
MKISTGLQRVFEDAQLVAQRYACEYLETWHILLAFVINHDTVAGAVLAEYPASISEYEHATFVVTEKVYREDLESFRILP
SSKRLDETASLAKKIAEVVKAKELGTEHLFLAMLLNRRSTASLILDKVGFHLEDSDDKIRFVDLRKSLEKRAGFTKEDMK
AVRGLMKGGKAKPVNAGQMMGMPPGPQTGGLEDYTRDLTALAREGKMEPVIGRDVEIERMIQILSRKTKNNPVLVGDAGV
GKTALALGLAQRVASGDVPVSLSKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQAEYQKHIEKDAALVRRFAKVMIEEPTVEDGIAILSGLKGTFEKYHRVRIGDRAV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRAKGQGELAESGLTSLDKALMAGKYKTVSKLLRQAKEAAKSSQNYDL
EVTEEDVLETLSRLSGIPVTKLSQSDAKKYLNLEAELHQRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGV
GKTELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNV
LLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKV
VFHSLTERHMQDVVKVMVKALLAVTAEKDITLKLQPSALKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGELPTG
STLKVGVKGEELKFDVVK

Nucleotide


Download         Length: 2457 bp        

>NTDB_id=794704 PW220_RS09215 WP_248055567.1 1846146..1848602(-) (clpC) [Streptococcus iners subsp. hyiners strain 29892]
ATGAAGATTTCAACTGGTTTACAAAGGGTGTTTGAAGATGCCCAGTTGGTCGCCCAACGCTATGCCTGTGAGTATTTGGA
AACCTGGCATATTCTCCTGGCCTTTGTCATCAATCACGATACGGTTGCTGGAGCAGTCTTGGCAGAATATCCTGCTTCTA
TTTCAGAGTATGAGCATGCGACCTTTGTCGTGACGGAGAAGGTCTATCGTGAAGACTTGGAGAGTTTTCGTATCTTGCCG
TCTTCTAAACGTTTGGATGAAACAGCAAGCTTAGCTAAAAAGATTGCGGAAGTGGTCAAGGCCAAGGAGTTGGGAACAGA
ACACCTTTTCCTAGCCATGTTGCTGAACAGACGTTCGACTGCCAGTCTGATTTTGGACAAGGTCGGTTTTCATTTGGAAG
ATTCCGATGACAAGATTCGTTTTGTAGATTTGCGCAAGAGCTTAGAAAAACGTGCAGGATTTACCAAGGAAGATATGAAG
GCTGTTCGTGGCTTGATGAAGGGCGGAAAAGCCAAGCCAGTCAATGCGGGACAGATGATGGGCATGCCTCCTGGACCTCA
AACGGGTGGTTTGGAAGACTATACCCGAGATTTGACTGCCCTGGCCCGAGAAGGCAAGATGGAACCGGTCATTGGCCGTG
ATGTCGAGATTGAGCGGATGATTCAAATCCTTTCCCGCAAGACGAAAAACAACCCTGTCCTAGTCGGTGATGCGGGTGTC
GGAAAAACGGCTCTTGCTTTGGGCTTGGCTCAACGTGTCGCTTCAGGTGATGTGCCTGTTAGTCTATCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAATGTGATTGCGGGCACTCGTTTCCGTGGTGACTTCGAAGAGCGGATGAACAATATCATCA
ATGACATTGAAGAAGACGGTCAGGTGATACTCTTCATCGATGAGCTGCACACGATTATGGGGTCTGGTTCAGGGATTGAT
TCGACTCTGGATGCGGCCAATATCCTCAAGCCGGCCCTGGCTCGTGGGACCCTTCGTACGGTTGGGGCGACCACTCAGGC
GGAGTATCAGAAGCATATCGAAAAAGATGCGGCCTTGGTACGTCGTTTTGCCAAGGTGATGATTGAGGAGCCGACTGTGG
AAGATGGCATTGCCATTTTGTCTGGTCTAAAAGGGACTTTTGAGAAATACCATAGGGTCCGTATTGGAGATAGGGCTGTT
GAAACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCAGCAATCGACTTGCTAGATGAAGC
CAGTGCAACCGTGCAAAATCGTGCCAAGGGACAGGGAGAATTGGCAGAATCTGGTTTGACCAGTCTGGATAAGGCTTTGA
TGGCTGGTAAGTATAAGACAGTTAGCAAGCTACTGCGTCAAGCAAAAGAAGCAGCTAAATCCAGTCAAAACTATGACTTG
GAAGTGACGGAAGAAGATGTCTTAGAAACCCTCAGTCGTCTGTCTGGTATTCCTGTGACCAAGCTTAGCCAGTCAGATGC
CAAGAAGTATTTGAATTTGGAAGCAGAATTACACCAGCGTGTCATTGGCCAGGAAGAAGCTATTTCTGCAGTCAGCAGGG
CCATCCGCCGTAATCAGTCAGGCATTCGGACAGGTCGCAGACCGATTGGTTCATTCATGTTCTTGGGACCGACGGGTGTC
GGTAAAACGGAGCTAGCTAAGGCCTTAGCAGAAGTCCTCTTTGATGACGAGTCAGCTCTGATTCGCTTTGACATGTCTGA
ATACATGGAGAAATTCGCAGCTAGCCGTCTAAATGGTGCCCCTCCAGGCTATGTTGGCTATGAAGAAGGTGGCGAATTAA
CAGAAAAAGTTCGTAATAAACCTTATTCTGTTCTTCTTTTTGATGAGGTTGAAAAAGCCCATCCAGATATTTTCAATGTG
CTCTTGCAGGTCTTGGATGATGGTGTCTTGACTGACAGTAAGGGACGCAAGGTTGATTTCTCCAATACCATCATTATCAT
GACCTCAAACCTAGGAGCGACAGCCCTTCGTGATGATAAGACAGTTGGTTTTGGGGCTCTTGATTTGTCTAAGGACCACA
AAGAAGTGGAGAAACGCATTTTTGAGGAATTGAAAAAGGCCTACCGTCCTGAATTTATCAACCGTATTGATGAAAAAGTG
GTCTTCCATAGCCTAACGGAAAGGCATATGCAGGATGTTGTCAAGGTCATGGTCAAAGCCTTGCTTGCGGTAACAGCTGA
GAAAGACATTACTCTCAAACTTCAGCCGTCTGCCCTTAAGTTGTTGGCTAAACAAGGTTACGACCCAGAAATGGGGGCTC
GCCCACTTCGCAGACTCTTGCAGACCAAGTTGGAAGATCCATTGGCAGAGATGTTGCTCCGTGGGGAGTTACCAACTGGT
TCAACCTTGAAAGTTGGGGTTAAGGGCGAAGAGCTCAAGTTTGATGTGGTCAAATAG

Domains

Predicted by InterproScan.

Clp amino terminal domain, pathogenicity island component (Clp_N)

(14-55)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(102-133)

ATPase family associated with various cellular activities (AAA) (AAA)

(233-366)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(725-805)

AAA lid domain (AAA_lid_9)

(373-444)

AAA domain (Cdc48 subfamily) (AAA_2)

(547-718)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae TIGR4

71.324

99.756

0.711
  clpC Streptococcus pneumoniae Rx1

71.324

99.756

0.711
  clpC Streptococcus pneumoniae D39

71.324

99.756

0.711
  clpC Streptococcus mutans UA159

66.176

99.756

0.66
  clpC Streptococcus thermophilus LMG 18311

65.201

100

0.653
  clpC Streptococcus thermophilus LMD-9

65.079

100

0.652
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

50

100

0.511
  clpC Bacillus subtilis subsp. subtilis str. 168

44.365

100

0.452