Detailed information NTG0792729

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PWK66_RS06180
• Genome accession: NZ_CP118482
• Coordinates: 1215316..1216353 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20160179
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1210316..1221353

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PWK66_RS06155 (PWK66_06095)	-	1210320..1210847 (-)	528	WP_002983837.1	Dps family protein	-
PWK66_RS06160 (PWK66_06100)	-	1211075..1211701 (+)	627	WP_002989076.1	A24 family peptidase	-
PWK66_RS06165 (PWK66_06105)	rlmN	1211783..1212862 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PWK66_RS06170 (PWK66_06110)	-	1212866..1213486 (-)	621	WP_032461520.1	YutD family protein	-
PWK66_RS06175 (PWK66_06115)	-	1213934..1214911 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PWK66_RS06180 (PWK66_06120)	sepM	1215316..1216353 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PWK66_RS06185 (PWK66_06125)	coaD	1216340..1216831 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PWK66_RS06190 (PWK66_06130)	rsmD	1216821..1217360 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PWK66_RS06195 (PWK66_06135)	asnA	1217483..1218475 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
PWK66_RS06200 (PWK66_06140)	arcC	1218789..1219739 (-)	951	WP_002989065.1	carbamate kinase	-
PWK66_RS06205 (PWK66_06145)	-	1219759..1221090 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=792729 PWK66_RS06180 WP_002989068.1 1215316..1216353(-) (sepM) [Streptococcus pyogenes strain 20160179]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=792729 PWK66_RS06180 WP_002989068.1 1215316..1216353(-) (sepM) [Streptococcus pyogenes strain 20160179]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69