Detailed information NTG0792677

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PWK65_RS06175
• Genome accession: NZ_CP118481
• Coordinates: 1211882..1212919 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20185322
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1206882..1217919

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PWK65_RS06150 (PWK65_06085)	-	1206886..1207413 (-)	528	WP_002983837.1	Dps family protein	-
PWK65_RS06155 (PWK65_06090)	-	1207641..1208267 (+)	627	WP_002989076.1	A24 family peptidase	-
PWK65_RS06160 (PWK65_06095)	rlmN	1208349..1209428 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PWK65_RS06165 (PWK65_06100)	-	1209432..1210052 (-)	621	WP_032461520.1	YutD family protein	-
PWK65_RS06170 (PWK65_06105)	-	1210500..1211477 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PWK65_RS06175 (PWK65_06110)	sepM	1211882..1212919 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PWK65_RS06180 (PWK65_06115)	coaD	1212906..1213397 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PWK65_RS06185 (PWK65_06120)	rsmD	1213387..1213926 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PWK65_RS06190 (PWK65_06125)	asnA	1214049..1215041 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
PWK65_RS06195 (PWK65_06130)	arcC	1215355..1216305 (-)	951	WP_002989065.1	carbamate kinase	-
PWK65_RS06200 (PWK65_06135)	-	1216325..1217656 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=792677 PWK65_RS06175 WP_002989068.1 1211882..1212919(-) (sepM) [Streptococcus pyogenes strain 20185322]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=792677 PWK65_RS06175 WP_002989068.1 1211882..1212919(-) (sepM) [Streptococcus pyogenes strain 20185322]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69