Detailed information NTG0791750

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PVK50_RS03785
• Genome accession: NZ_CP118311
• Coordinates: 734917..735954 (+)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20164915
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 729917..740954

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK50_RS03760 (PVK50_03725)	-	730180..731511 (+)	1332	WP_002989063.1	dipeptidase	-
PVK50_RS03765 (PVK50_03730)	arcC	731531..732481 (+)	951	WP_002989065.1	carbamate kinase	-
PVK50_RS03770 (PVK50_03735)	asnA	732795..733787 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
PVK50_RS03775 (PVK50_03740)	rsmD	733910..734449 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PVK50_RS03780 (PVK50_03745)	coaD	734439..734930 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PVK50_RS03785 (PVK50_03750)	sepM	734917..735954 (+)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PVK50_RS03790 (PVK50_03755)	-	736359..737336 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PVK50_RS03795 (PVK50_03760)	-	737784..738404 (+)	621	WP_397610652.1	YutD family protein	-
PVK50_RS03800 (PVK50_03765)	rlmN	738408..739487 (+)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PVK50_RS03805 (PVK50_03770)	-	739569..740195 (-)	627	WP_002989076.1	A24 family peptidase	-
PVK50_RS03810 (PVK50_03775)	-	740423..740950 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=791750 PVK50_RS03785 WP_002989068.1 734917..735954(+) (sepM) [Streptococcus pyogenes strain 20164915]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=791750 PVK50_RS03785 WP_002989068.1 734917..735954(+) (sepM) [Streptococcus pyogenes strain 20164915]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69