Detailed information NTG0791698

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PVK51_RS04970
• Genome accession: NZ_CP118310
• Coordinates: 935146..936183 (+)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20154051
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 930146..941183

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK51_RS04945 (PVK51_04915)	-	930409..931740 (+)	1332	WP_002989063.1	dipeptidase	-
PVK51_RS04950 (PVK51_04920)	arcC	931760..932710 (+)	951	WP_002989065.1	carbamate kinase	-
PVK51_RS04955 (PVK51_04925)	asnA	933024..934016 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
PVK51_RS04960 (PVK51_04930)	rsmD	934139..934678 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PVK51_RS04965 (PVK51_04935)	coaD	934668..935159 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PVK51_RS04970 (PVK51_04940)	sepM	935146..936183 (+)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PVK51_RS04975 (PVK51_04945)	-	936588..937565 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PVK51_RS04980 (PVK51_04950)	-	938013..938633 (+)	621	WP_397610652.1	YutD family protein	-
PVK51_RS04985 (PVK51_04955)	rlmN	938637..939716 (+)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PVK51_RS04990 (PVK51_04960)	-	939798..940424 (-)	627	WP_002989076.1	A24 family peptidase	-
PVK51_RS04995 (PVK51_04965)	-	940652..941179 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=791698 PVK51_RS04970 WP_002989068.1 935146..936183(+) (sepM) [Streptococcus pyogenes strain 20154051]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=791698 PVK51_RS04970 WP_002989068.1 935146..936183(+) (sepM) [Streptococcus pyogenes strain 20154051]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69