Detailed information NTG0791635

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PVK55_RS03090
• Genome accession: NZ_CP118309
• Coordinates: 589217..590254 (+)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20192362
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 584217..595254

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK55_RS03065 (PVK55_03035)	-	584480..585811 (+)	1332	WP_002989063.1	dipeptidase	-
PVK55_RS03070 (PVK55_03040)	arcC	585831..586781 (+)	951	WP_002989065.1	carbamate kinase	-
PVK55_RS03075 (PVK55_03045)	asnA	587095..588087 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
PVK55_RS03080 (PVK55_03050)	rsmD	588210..588749 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PVK55_RS03085 (PVK55_03055)	coaD	588739..589230 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PVK55_RS03090 (PVK55_03060)	sepM	589217..590254 (+)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PVK55_RS03095 (PVK55_03065)	-	590659..591636 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PVK55_RS03100 (PVK55_03070)	-	592084..592704 (+)	621	WP_397610652.1	YutD family protein	-
PVK55_RS03105 (PVK55_03075)	rlmN	592708..593787 (+)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PVK55_RS03110 (PVK55_03080)	-	593869..594495 (-)	627	WP_002989076.1	A24 family peptidase	-
PVK55_RS03115 (PVK55_03085)	-	594723..595250 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=791635 PVK55_RS03090 WP_002989068.1 589217..590254(+) (sepM) [Streptococcus pyogenes strain 20192362]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=791635 PVK55_RS03090 WP_002989068.1 589217..590254(+) (sepM) [Streptococcus pyogenes strain 20192362]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69