Detailed information NTG0791590

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PVK53_RS06450
• Genome accession: NZ_CP118308
• Coordinates: 1254976..1256013 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20203206
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1249976..1261013

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK53_RS06425 (PVK53_06375)	-	1249980..1250507 (-)	528	WP_002983837.1	Dps family protein	-
PVK53_RS06430 (PVK53_06380)	-	1250735..1251361 (+)	627	WP_002989076.1	A24 family peptidase	-
PVK53_RS06435 (PVK53_06385)	rlmN	1251443..1252522 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PVK53_RS06440 (PVK53_06390)	-	1252526..1253146 (-)	621	WP_397610652.1	YutD family protein	-
PVK53_RS06445 (PVK53_06395)	-	1253594..1254571 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PVK53_RS06450 (PVK53_06400)	sepM	1254976..1256013 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PVK53_RS06455 (PVK53_06405)	coaD	1256000..1256491 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PVK53_RS06460 (PVK53_06410)	rsmD	1256481..1257020 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PVK53_RS06465 (PVK53_06415)	asnA	1257143..1258135 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
PVK53_RS06470 (PVK53_06420)	arcC	1258449..1259399 (-)	951	WP_002989065.1	carbamate kinase	-
PVK53_RS06475 (PVK53_06425)	-	1259419..1260750 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=791590 PVK53_RS06450 WP_002989068.1 1254976..1256013(-) (sepM) [Streptococcus pyogenes strain 20203206]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=791590 PVK53_RS06450 WP_002989068.1 1254976..1256013(-) (sepM) [Streptococcus pyogenes strain 20203206]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69