Detailed information NTG0791535

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PVK48_RS06455
• Genome accession: NZ_CP118307
• Coordinates: 1255025..1256062 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain 20200554
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1250025..1261062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK48_RS06430 (PVK48_06370)	-	1250029..1250556 (-)	528	WP_002983837.1	Dps family protein	-
PVK48_RS06435 (PVK48_06375)	-	1250784..1251410 (+)	627	WP_002989076.1	A24 family peptidase	-
PVK48_RS06440 (PVK48_06380)	rlmN	1251492..1252571 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PVK48_RS06445 (PVK48_06385)	-	1252575..1253195 (-)	621	WP_397610652.1	YutD family protein	-
PVK48_RS06450 (PVK48_06390)	-	1253643..1254620 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
PVK48_RS06455 (PVK48_06395)	sepM	1255025..1256062 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
PVK48_RS06460 (PVK48_06400)	coaD	1256049..1256540 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PVK48_RS06465 (PVK48_06405)	rsmD	1256530..1257069 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PVK48_RS06470 (PVK48_06410)	asnA	1257192..1258184 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
PVK48_RS06475 (PVK48_06415)	arcC	1258498..1259448 (-)	951	WP_002989065.1	carbamate kinase	-
PVK48_RS06480 (PVK48_06420)	-	1259468..1260799 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=791535 PVK48_RS06455 WP_002989068.1 1255025..1256062(-) (sepM) [Streptococcus pyogenes strain 20200554]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=791535 PVK48_RS06455 WP_002989068.1 1255025..1256062(-) (sepM) [Streptococcus pyogenes strain 20200554]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69