Detailed information NTG0782863

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: PQQ74_RS09415
• Genome accession: NZ_CP117203
• Coordinates: 1932191..1933234 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 2022QW-00133
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1927191..1938234

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PQQ74_RS09385 (PQQ74_09385)	-	1927609..1928865 (-)	1257	WP_001795438.1	aminopeptidase	-
PQQ74_RS09390 (PQQ74_09390)	-	1928868..1929068 (-)	201	WP_000180461.1	DUF1128 family protein	-
PQQ74_RS09395 (PQQ74_09395)	-	1929215..1929679 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
PQQ74_RS09400 (PQQ74_09400)	-	1929686..1929961 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
PQQ74_RS09405 (PQQ74_09405)	-	1930239..1931456 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
PQQ74_RS09410 (PQQ74_09410)	vraR	1931572..1932201 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
PQQ74_RS09415 (PQQ74_09415)	vraS	1932191..1933234 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
PQQ74_RS09420 (PQQ74_09420)	liaF	1933231..1933932 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
PQQ74_RS09425 (PQQ74_09425)	-	1933947..1934333 (-)	387	WP_001110179.1	hypothetical protein	-
PQQ74_RS09430 (PQQ74_09430)	map	1934550..1935308 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
PQQ74_RS09435 (PQQ74_09435)	-	1935836..1936822 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
PQQ74_RS09440 (PQQ74_09440)	-	1937312..1937725 (-)	414	WP_001549145.1	hypothetical protein	-
PQQ74_RS09445 (PQQ74_09445)	-	1937754..1937864 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=782863 PQQ74_RS09415 WP_001017131.1 1932191..1933234(-) (vraS) [Staphylococcus aureus strain 2022QW-00133]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=782863 PQQ74_RS09415 WP_001017131.1 1932191..1933234(-) (vraS) [Staphylococcus aureus strain 2022QW-00133]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1