Detailed information NTG0778604

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PML78_RS00155
• Genome accession: NZ_CP116583
• Coordinates: 35838..36860 (+)
• Length: 340 a.a.
• NCBI ID: WP_016171771.1
• Uniprot ID: S1N8E9
• Organism: Enterococcus dispar strain K205-4b
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 30838..41860

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PML78_RS00130 (PML78_00130)	-	32671..33780 (+)	1110	WP_016171766.1	CAP-associated domain-containing protein	-
PML78_RS00135 (PML78_00135)	-	33782..34210 (+)	429	WP_016171767.1	YlbF family regulator	-
PML78_RS00140 (PML78_00140)	-	34200..34550 (+)	351	WP_016171768.1	YlbG family protein	-
PML78_RS00145 (PML78_00145)	rsmD	34798..35361 (+)	564	WP_016171769.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PML78_RS00150 (PML78_00150)	coaD	35354..35848 (+)	495	WP_016171770.1	pantetheine-phosphate adenylyltransferase	-
PML78_RS00155 (PML78_00155)	sepM	35838..36860 (+)	1023	WP_016171771.1	SepM family pheromone-processing serine protease	Regulator
PML78_RS00160 (PML78_00160)	-	36956..37336 (+)	381	WP_016171772.1	DUF1149 family protein	-
PML78_RS00165 (PML78_00165)	-	37346..37720 (+)	375	WP_016171773.1	VOC family protein	-
PML78_RS00170 (PML78_00170)	-	37890..39113 (-)	1224	WP_195516295.1	ABC transporter permease	-
PML78_RS00175 (PML78_00175)	-	39126..39818 (-)	693	WP_016171775.1	ABC transporter ATP-binding protein	-
PML78_RS00180 (PML78_00180)	-	39827..40687 (-)	861	WP_016171776.1	efflux RND transporter periplasmic adaptor subunit	-
PML78_RS00185 (PML78_00185)	-	40821..41555 (+)	735	WP_016171777.1	metallophosphoesterase	-

Sequence

Protein

• Length: 340 a.a.
• Molecular weight: 37116.75 Da
• Isoelectric Point: 9.4800

>NTDB_id=778604 PML78_RS00155 WP_016171771.1 35838..36860(+) (sepM) [Enterococcus dispar strain K205-4b]
MKRKVPIKRLLLLLFALILMACVALPIPYYIEAPGSTIKLDTLVKVNDKKDKFSGSFSLTSVGIRQATVATALFAKTQAF
SDLVTKEALMGTASDDDYNRIQNFYMETSQNNAITAALTLADQPFKMDYLGVYVLGIEKNSAFYGKIKIGDTVVKVDSQV
FKSSNDFMKYVQSKKVDDKVTITYLQDGKEKEASGSLIKLPSNGKAGIGITLTDHTQVNSQEKVQFDVDNIGGPSAGLMF
TLEIYQQLIKQDLRNGHEIAGTGTIDSQGNVGQIGGIDKKIVSASESGAEIFFAPADLEKGDTNYQDAKKAAKKINTKMK
VIPVKTAQEAVKYLKEHVAK

Nucleotide

• Length: 1023 bp

>NTDB_id=778604 PML78_RS00155 WP_016171771.1 35838..36860(+) (sepM) [Enterococcus dispar strain K205-4b]
ATGAAGCGTAAAGTCCCAATTAAACGTCTCTTACTTTTATTATTTGCTCTAATTTTAATGGCCTGTGTGGCATTGCCGAT
TCCTTATTATATTGAAGCCCCGGGTTCTACCATTAAGCTGGATACTTTGGTTAAAGTGAATGACAAAAAAGATAAGTTTA
GTGGCTCTTTTTCTTTGACTTCTGTTGGGATTCGACAAGCAACTGTCGCAACAGCACTATTTGCCAAAACGCAAGCTTTC
TCTGATTTGGTAACAAAAGAAGCGTTGATGGGAACTGCCAGCGACGATGATTATAATCGTATTCAAAATTTTTATATGGA
AACTTCACAAAATAACGCCATTACAGCTGCCCTGACTTTAGCGGATCAACCGTTTAAAATGGACTATCTCGGTGTTTATG
TCTTGGGGATTGAAAAAAACTCTGCATTTTATGGCAAAATTAAAATTGGTGATACTGTGGTGAAAGTAGATTCGCAGGTT
TTTAAAAGTAGTAATGACTTTATGAAATATGTTCAAAGTAAAAAAGTAGATGATAAAGTTACCATAACTTATCTGCAAGA
TGGTAAAGAAAAAGAAGCGAGCGGTTCTTTAATTAAATTACCAAGTAATGGTAAAGCGGGAATCGGAATTACCCTAACCG
ACCATACGCAAGTAAACAGTCAGGAAAAAGTCCAGTTTGATGTGGATAATATTGGTGGTCCATCGGCAGGATTGATGTTT
ACTTTAGAAATATACCAACAGTTAATTAAACAAGATTTACGCAATGGTCATGAAATTGCTGGTACAGGAACTATTGACAG
TCAAGGAAATGTGGGCCAAATTGGCGGAATTGATAAAAAAATTGTCAGTGCTTCTGAAAGCGGAGCCGAAATTTTCTTTG
CGCCGGCAGATTTAGAAAAAGGGGATACCAATTATCAAGACGCTAAAAAAGCAGCTAAAAAAATTAATACCAAGATGAAA
GTCATACCGGTCAAGACGGCACAAGAAGCTGTAAAATATTTGAAAGAACATGTGGCAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-333)

• PDZ domain (PDZ_2) (126-194)

3D structure

• AlphaFold DB: S1N8E9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	47.839	100	0.488