Detailed information NTG0777448

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: PJV85_RS06310
• Genome accession: NZ_CP116457
• Coordinates: 1272609..1273646 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1095
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1267609..1278646

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PJV85_RS06285 (PJV85_06285)	-	1267613..1268140 (-)	528	WP_002983837.1	Dps family protein	-
PJV85_RS06290 (PJV85_06290)	-	1268368..1268994 (+)	627	WP_002983834.1	prepilin peptidase	-
PJV85_RS06295 (PJV85_06295)	rlmN	1269076..1270155 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
PJV85_RS06300 (PJV85_06300)	-	1270159..1270779 (-)	621	WP_002992791.1	YutD family protein	-
PJV85_RS06305 (PJV85_06305)	-	1271227..1272204 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
PJV85_RS06310 (PJV85_06310)	sepM	1272609..1273646 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
PJV85_RS06315 (PJV85_06315)	coaD	1273633..1274124 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
PJV85_RS06320 (PJV85_06320)	rsmD	1274114..1274653 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
PJV85_RS06325 (PJV85_06325)	asnA	1274776..1275768 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
PJV85_RS06330 (PJV85_06330)	arcC	1276081..1277031 (-)	951	WP_009880962.1	carbamate kinase	-
PJV85_RS06335 (PJV85_06335)	-	1277051..1278382 (-)	1332	WP_136273999.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=777448 PJV85_RS06310 WP_010922499.1 1272609..1273646(-) (sepM) [Streptococcus pyogenes strain 1095]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=777448 PJV85_RS06310 WP_010922499.1 1272609..1273646(-) (sepM) [Streptococcus pyogenes strain 1095]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693