Detailed information NTG0774180

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: PCM89_RS09655
• Genome accession: NZ_CP115887
• Coordinates: 1975505..1976548 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain C308
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1970505..1981548

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PCM89_RS09625 (PCM89_09625)	-	1970926..1972182 (-)	1257	WP_075583716.1	aminopeptidase	-
PCM89_RS09630 (PCM89_09630)	-	1972185..1972385 (-)	201	WP_000180460.1	DUF1128 family protein	-
PCM89_RS09635 (PCM89_09635)	-	1972532..1972996 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
PCM89_RS09640 (PCM89_09640)	-	1973003..1973278 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
PCM89_RS09645 (PCM89_09645)	-	1973556..1974773 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
PCM89_RS09650 (PCM89_09650)	vraR	1974886..1975515 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
PCM89_RS09655 (PCM89_09655)	vraS	1975505..1976548 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
PCM89_RS09660 (PCM89_09660)	liaF	1976545..1977246 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
PCM89_RS09665 (PCM89_09665)	-	1977261..1977647 (-)	387	WP_001110179.1	hypothetical protein	-
PCM89_RS09670 (PCM89_09670)	map	1977864..1978622 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
PCM89_RS09675 (PCM89_09675)	-	1979151..1980137 (+)	987	WP_000999713.1	FUSC family protein	-
PCM89_RS09680 (PCM89_09680)	-	1980568..1980981 (-)	414	WP_001670387.1	hypothetical protein	-
PCM89_RS09685 (PCM89_09685)	-	1981010..1981120 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=774180 PCM89_RS09655 WP_001017131.1 1975505..1976548(-) (vraS) [Staphylococcus aureus strain C308]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=774180 PCM89_RS09655 WP_001017131.1 1975505..1976548(-) (vraS) [Staphylococcus aureus strain C308]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1