Detailed information NTG0772460

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: PDI59_RS13735
• Genome accession: NZ_CP115478
• Coordinates: 2744061..2745410 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain HP20814-062
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2724070..2745410	2744061..2745410	within	0

Gene organization within MGE regions

Location: 2724070..2745410

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PDI59_RS13635 (PDI59_13635)	mecA	2724070..2726079 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
PDI59_RS13640 (PDI59_13640)	mecR1	2726176..2727933 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
PDI59_RS13645 (PDI59_13645)	mecI	2727933..2728304 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
PDI59_RS13650 (PDI59_13650)	psm-mec	2728389..2728457 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
PDI59_RS13655 (PDI59_13655)	-	2728812..2729921 (+)	1110	WP_000943131.1	ROK family transcriptional regulator	-
PDI59_RS13660 (PDI59_13660)	cstB	2730035..2731369 (-)	1335	Protein_2652	persulfide dioxygenase-sulfurtransferase CstB	-
PDI59_RS13665 (PDI59_13665)	-	2731402..2732466 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
PDI59_RS13670 (PDI59_13670)	cstR	2732602..2732862 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
PDI59_RS13675 (PDI59_13675)	-	2732862..2733500 (+)	639	Protein_2655	sulfite exporter TauE/SafE family protein	-
PDI59_RS13680 (PDI59_13680)	-	2733845..2734507 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
PDI59_RS14405	-	2734899..2734958 (+)	60	WP_010959190.1	erythromycin resistance leader peptide	-
PDI59_RS13685 (PDI59_13685)	erm(A)	2735016..2735747 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
PDI59_RS13690 (PDI59_13690)	-	2735873..2736655 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
PDI59_RS13695 (PDI59_13695)	-	2736806..2737183 (-)	378	WP_000361059.1	DUF6262 family protein	-
PDI59_RS13700 (PDI59_13700)	-	2737190..2739082 (-)	1893	WP_001557544.1	site-specific integrase	-
PDI59_RS13705 (PDI59_13705)	-	2739079..2740164 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
PDI59_RS13710 (PDI59_13710)	-	2740283..2740600 (-)	318	WP_000659050.1	JAB domain-containing protein	-
PDI59_RS13715 (PDI59_13715)	-	2740621..2741127 (-)	507	WP_001092169.1	DUF1643 domain-containing protein	-
PDI59_RS13720 (PDI59_13720)	-	2741145..2741456 (-)	312	WP_000700853.1	DUF960 family protein	-
PDI59_RS13725 (PDI59_13725)	-	2741543..2741893 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
PDI59_RS13730 (PDI59_13730)	ccrB	2742411..2744039 (-)	1629	WP_001186602.1	recombinase family protein	Machinery gene
PDI59_RS13735 (PDI59_13735)	ccrA	2744061..2745410 (-)	1350	WP_000815646.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=772460 PDI59_RS13735 WP_000815646.1 2744061..2745410(-) (ccrA) [Staphylococcus aureus strain HP20814-062]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=772460 PDI59_RS13735 WP_000815646.1 2744061..2745410(-) (ccrA) [Staphylococcus aureus strain HP20814-062]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748