Detailed information NTG0772322

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: PDI58_RS10600
• Genome accession: NZ_CP115474
• Coordinates: 2087156..2088505 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain AF4005
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2087156..2108495	2087156..2088505	within	0

Gene organization within MGE regions

Location: 2087156..2108495

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PDI58_RS10600 (PDI58_10600)	ccrA	2087156..2088505 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
PDI58_RS10605 (PDI58_10605)	ccrB	2088527..2090155 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
PDI58_RS10610 (PDI58_10610)	-	2090673..2091023 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
PDI58_RS10615 (PDI58_10615)	-	2091110..2091421 (+)	312	WP_000700853.1	DUF960 family protein	-
PDI58_RS10620 (PDI58_10620)	-	2091439..2091945 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
PDI58_RS10625 (PDI58_10625)	-	2091966..2092283 (+)	318	WP_000659050.1	JAB domain-containing protein	-
PDI58_RS10630 (PDI58_10630)	-	2092402..2093487 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
PDI58_RS10635 (PDI58_10635)	-	2093484..2095376 (+)	1893	WP_001557544.1	site-specific integrase	-
PDI58_RS10640 (PDI58_10640)	-	2095383..2095760 (+)	378	WP_000361059.1	DUF6262 family protein	-
PDI58_RS10645 (PDI58_10645)	-	2095911..2096693 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
PDI58_RS10650 (PDI58_10650)	erm(A)	2096819..2097550 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
PDI58_RS14900	-	2097608..2097667 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
PDI58_RS10655 (PDI58_10655)	-	2098059..2098721 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
PDI58_RS10660 (PDI58_10660)	-	2099066..2099704 (-)	639	Protein_2070	sulfite exporter TauE/SafE family protein	-
PDI58_RS10665 (PDI58_10665)	cstR	2099704..2099964 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
PDI58_RS10670 (PDI58_10670)	-	2100100..2101164 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
PDI58_RS10675 (PDI58_10675)	cstB	2101196..2102530 (+)	1335	Protein_2073	persulfide dioxygenase-sulfurtransferase CstB	-
PDI58_RS10680 (PDI58_10680)	-	2102644..2103753 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
PDI58_RS10685 (PDI58_10685)	psm-mec	2104108..2104176 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
PDI58_RS10690 (PDI58_10690)	mecI	2104261..2104632 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
PDI58_RS10695 (PDI58_10695)	mecR1	2104632..2106389 (-)	1758	WP_216798524.1	beta-lactam sensor/signal transducer MecR1	-
PDI58_RS10700 (PDI58_10700)	mecA	2106486..2108495 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=772322 PDI58_RS10600 WP_000815646.1 2087156..2088505(+) (ccrA) [Staphylococcus aureus strain AF4005]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=772322 PDI58_RS10600 WP_000815646.1 2087156..2088505(+) (ccrA) [Staphylococcus aureus strain AF4005]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748