Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   OS912_RS04865 Genome accession   NZ_CP113266
Coordinates   965761..966585 (-) Length   274 a.a.
NCBI ID   WP_001036784.1    Uniprot ID   A0A0E7E4I0
Organism   Streptococcus pneumoniae strain BC1     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Genomic Context

Location: 960761..971585
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS912_RS04860 (OS912_04865) - 964139..965470 (-) 1332 WP_000390039.1 hemolysin family protein -
  OS912_RS04865 (OS912_04870) endA 965761..966585 (-) 825 WP_001036784.1 DNA-entry nuclease EndA Machinery gene
  OS912_RS04870 (OS912_04875) - 966624..966812 (-) 189 WP_001813390.1 DNA-directed RNA polymerase subunit beta -
  OS912_RS04875 (OS912_04880) murA 966805..968088 (-) 1284 WP_000358028.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  OS912_RS04880 (OS912_04885) - 968112..968342 (-) 231 WP_000250392.1 DUF1146 family protein -
  OS912_RS04885 (OS912_04890) sepM 968400..969437 (-) 1038 WP_000727273.1 SepM family pheromone-processing serine protease Regulator
  OS912_RS04890 (OS912_04895) coaD 969421..969909 (-) 489 WP_001280751.1 pantetheine-phosphate adenylyltransferase -
  OS912_RS04895 (OS912_04900) rsmD 969899..970438 (-) 540 WP_000706963.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  OS912_RS04900 (OS912_04905) asnA 970503..971495 (-) 993 WP_061816329.1 aspartate--ammonia ligase -

Sequence

Protein


Download         Length: 274 a.a.        Molecular weight: 29931.63 Da        Isoelectric Point: 10.1197

>NTDB_id=761406 OS912_RS04865 WP_001036784.1 965761..966585(-) (endA) [Streptococcus pneumoniae strain BC1]
MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSAPNSPKTNLSQKKQAPEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIV
NGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDLVPSASQIE
AKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ

Nucleotide


Download         Length: 825 bp        

>NTDB_id=761406 OS912_RS04865 WP_001036784.1 965761..966585(-) (endA) [Streptococcus pneumoniae strain BC1]
ATGAACAAAAAAACAAGACAGACACTAATCGGACTGCTAGTGTTATTGCTTTTGTCTACAGGGAGCTATTATATCAAGCA
GATGCAGTCGGCACCTAATAGTCCCAAAACCAATCTTAGTCAGAAAAAACAAGCGCCTGAAGCTCCTAGTCAAGCATTGG
CAGAGAGTGTCTTAACAGACGCAGTCAAGAGTCAAATAAAGGGGAGTCTGGAGTGGAATGGCTCAGGTGCTTTTATCGTC
AATGGTAATAAAACAAATCTAGATGCCAAGGTTTCAAGTAAGCCCTACGCTGACAATAAAACAAAGACAGTGGGCAAGGA
AACTGTTCCAACCGTAGCTAATGCCCTCTTGTCTAAGGCCACTCGTCAGTACAAGAATCGTAAAGAAACTGGGAATGGTT
CAACTTCTTGGACTCCTCCAGGTTGGCATCAGGTCAAGAATCTAAAGGGCTCTTATACCCATGCAGTCGATAGAGGTCAT
TTGTTAGGCTATGCCTTAATCGGTGGTTTGGATGGTTTTGATGCCTCAACAAGCAATCCTAAAAACATTGCTGTTCAGAC
AGCCTGGGCAAATCAGGCACAAGCCGAGTATTCGACTGGTCAAAACTACTATGAAAGCAAGGTGCGTAAAGCCTTGGACC
AAAACAAGCGTGTCCGTTACCGTGTAACCCTTTACTACGCTTCAAACGAGGATTTAGTTCCCTCAGCTTCACAGATTGAA
GCCAAGTCTTCGGATGGAGAATTGGAATTCAATGTTCTAGTTCCCAATGTTCAAAAGGGACTTCAACTGGATTACCGAAC
TGGAGAAGTAACTGTAACTCAGTAA

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(75-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E7E4I0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

99.27

100

0.993
  endA Streptococcus pneumoniae D39

99.27

100

0.993
  endA Streptococcus pneumoniae R6

99.27

100

0.993
  endA Streptococcus pneumoniae TIGR4

99.27

100

0.993