Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   OS088_RS12790 Genome accession   NZ_CP113051
Coordinates   2512357..2513706 (-) Length   449 a.a.
NCBI ID   WP_000815654.1    Uniprot ID   Q4JFB2
Organism   Staphylococcus aureus strain Viktor     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2510638..2534926 2512357..2513706 within 0
SCCmec 2492337..2517768 2512357..2513706 within 0


Gene organization within MGE regions


Location: 2492337..2534926
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS088_RS12690 mecA 2492337..2494346 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  OS088_RS12695 mecR1 2494443..2496200 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  OS088_RS12700 mecI 2496200..2496571 (+) 372 WP_267814210.1 mecA-type methicillin resistance repressor MecI -
  OS088_RS12705 psm-mec 2496656..2496724 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  OS088_RS12710 - 2497058..2498188 (+) 1131 WP_010922808.1 ROK family transcriptional regulator -
  OS088_RS12715 cstB 2498302..2499637 (-) 1336 Protein_2460 persulfide dioxygenase-sulfurtransferase CstB -
  OS088_RS12720 - 2499669..2500733 (-) 1065 WP_267814212.1 DsrE/DsrF/DrsH-like family protein -
  OS088_RS12725 cstR 2500869..2501129 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  OS088_RS12730 - 2501129..2501758 (+) 630 Protein_2463 sulfite exporter TauE/SafE family protein -
  OS088_RS14535 - 2501720..2501824 (-) 105 WP_112368216.1 hypothetical protein -
  OS088_RS12735 - 2502113..2502776 (-) 664 Protein_2465 class I SAM-dependent methyltransferase -
  OS088_RS14540 - 2503168..2503227 (+) 60 WP_010959190.1 erythromycin resistance leader peptide -
  OS088_RS12740 erm(A) 2503310..2504041 (+) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  OS088_RS12745 - 2504167..2504949 (-) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  OS088_RS12750 - 2505100..2505477 (-) 378 WP_000361059.1 DUF6262 family protein -
  OS088_RS12755 - 2505484..2507313 (-) 1830 WP_001666399.1 site-specific integrase -
  OS088_RS12760 - 2507374..2508459 (-) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  OS088_RS12765 - 2508578..2508895 (-) 318 WP_000659050.1 JAB domain-containing protein -
  OS088_RS12770 - 2508916..2509422 (-) 507 WP_001092169.1 DUF1643 domain-containing protein -
  OS088_RS12775 - 2509440..2509751 (-) 312 WP_000700853.1 DUF960 family protein -
  OS088_RS12780 - 2509838..2510188 (-) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  OS088_RS12785 ccrB 2510707..2512335 (-) 1629 Protein_2476 cassette chromosome recombinase CcrB -
  OS088_RS12790 ccrA 2512357..2513706 (-) 1350 WP_000815654.1 cassette chromosome recombinase CcrA Machinery gene
  OS088_RS12795 cch1 2513940..2515727 (-) 1788 WP_001573627.1 cassette chromosome replicative helicase -
  OS088_RS12800 ssb 2515727..2516023 (-) 297 Protein_2479 cassette chromosome ssDNA-binding protein -
  OS088_RS12805 - 2516323..2517882 (-) 1560 WP_031790038.1 hypothetical protein -
  OS088_RS12810 - 2518268..2519212 (-) 945 WP_048520175.1 ATP-binding protein -
  OS088_RS12815 - 2519495..2519674 (+) 180 WP_154284439.1 hypothetical protein -
  OS088_RS12820 - 2519928..2520851 (+) 924 WP_267814216.1 hypothetical protein -
  OS088_RS12825 - 2520956..2521315 (+) 360 WP_267814217.1 hypothetical protein -
  OS088_RS12830 - 2521278..2521589 (+) 312 WP_267814219.1 DDE-type integrase/transposase/recombinase -
  OS088_RS12835 - 2521549..2522193 (+) 645 WP_267814221.1 Mu transposase domain-containing protein -
  OS088_RS12840 istB 2522205..2522972 (+) 768 WP_086094926.1 IS21-like element helper ATPase IstB -
  OS088_RS12845 - 2523033..2523380 (+) 348 WP_267814222.1 hypothetical protein -
  OS088_RS12850 - 2523340..2523924 (+) 585 WP_267814223.1 DUF4209 domain-containing protein -
  OS088_RS12855 - 2523962..2524309 (+) 348 WP_241664859.1 hypothetical protein -
  OS088_RS12860 - 2524509..2525126 (+) 618 WP_267814226.1 hypothetical protein -
  OS088_RS12865 - 2525564..2525722 (+) 159 WP_195758897.1 hypothetical protein -
  OS088_RS12870 selZ 2526101..2526877 (+) 777 WP_154284306.1 staphylococcal enterotoxin type Z -
  OS088_RS12875 - 2527062..2528048 (-) 987 WP_000662036.1 tRNA dihydrouridine synthase -
  OS088_RS12880 - 2528357..2528560 (+) 204 WP_154284307.1 DUF6007 family protein -
  OS088_RS12885 - 2528609..2528905 (+) 297 WP_154284308.1 TfoX/Sxy family protein -
  OS088_RS12890 - 2529114..2529716 (+) 603 WP_267815141.1 hypothetical protein -
  OS088_RS12895 - 2529983..2533135 (+) 3153 WP_209205686.1 DEAD/DEAH box helicase -
  OS088_RS12900 - 2533210..2533692 (+) 483 WP_154284310.1 hypothetical protein -
  OS088_RS12905 - 2533897..2534883 (+) 987 WP_154284311.1 phosphatidylinositol-specific phospholipase C -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52665.36 Da        Isoelectric Point: 10.0809

>NTDB_id=759606 OS088_RS12790 WP_000815654.1 2512357..2513706(-) (ccrA) [Staphylococcus aureus strain Viktor]
MKQVIGYLRQSTMKQQSLAAQKQAIEAITEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQKQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQNTIQ
NIIQKRFTLNMLYPYIDEILITKSKTLMGIYFKNEPLNIVNQTTQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=759606 OS088_RS12790 WP_000815654.1 2512357..2513706(-) (ccrA) [Staphylococcus aureus strain Viktor]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAACCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTGCATGATGGTTATTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATTATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAAAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAAAACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATGCTGTATCCCTACATTGATGAAATTCTTATCACAAAAAGTAAAACACT
AATGGGTATCTATTTCAAAAATGAACCCTTAAACATCGTCAATCAAACAACGCAATCGTCAATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4JFB2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

95.323

100

0.953
  ccrA Staphylococcus aureus COL

75.501

100

0.755