Detailed information NTG0759368

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: OS086_RS06175
• Genome accession: NZ_CP113039
• Coordinates: 1191960..1193588 (-)
• Length: 542 a.a.
• NCBI ID: WP_001186602.1
• Uniprot ID: Q9XB94
• Organism: Staphylococcus aureus strain Gwen
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	1173594..1194959	1191960..1193588	within	0

Gene organization within MGE regions

Location: 1173594..1194959

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OS086_RS06080	mecA	1173594..1175603 (-)	2010	WP_267811135.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
OS086_RS06085	mecR1	1175700..1177457 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
OS086_RS06090	mecI	1177457..1177828 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
OS086_RS06095	psm-mec	1177913..1177981 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
OS086_RS06100	-	1178315..1179445 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
OS086_RS06105	cstB	1179559..1180893 (-)	1335	Protein_1175	persulfide dioxygenase-sulfurtransferase CstB	-
OS086_RS06110	-	1180926..1181990 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
OS086_RS06115	cstR	1182126..1182386 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
OS086_RS06120	-	1182386..1183024 (+)	639	Protein_1178	sulfite exporter TauE/SafE family protein	-
OS086_RS14765	-	1183078..1183137 (-)	60	Protein_1179	DNA repair protein RadC	-
OS086_RS06125	-	1183369..1184031 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
OS086_RS14770	-	1184423..1184482 (+)	60	WP_010959190.1	erythromycin resistance leader peptide	-
OS086_RS06130	erm(A)	1184565..1185296 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
OS086_RS06135	-	1185422..1186204 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
OS086_RS06140	-	1186355..1186732 (-)	378	WP_000361059.1	DUF6262 family protein	-
OS086_RS06145	-	1186739..1188631 (-)	1893	WP_001557544.1	site-specific integrase	-
OS086_RS06150	-	1188628..1189713 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
OS086_RS06155	-	1189832..1190149 (-)	318	WP_000659050.1	JAB domain-containing protein	-
OS086_RS06160	-	1190170..1190676 (-)	507	WP_001092169.1	DUF1643 domain-containing protein	-
OS086_RS06165	-	1190694..1191005 (-)	312	WP_000700853.1	DUF960 family protein	-
OS086_RS06170	-	1191092..1191442 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
OS086_RS06175	ccrB	1191960..1193588 (-)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
OS086_RS06180	ccrA	1193610..1194959 (-)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62664.84 Da
• Isoelectric Point: 9.8600

>NTDB_id=759368 OS086_RS06175 WP_001186602.1 1191960..1193588(-) (ccrB) [Staphylococcus aureus strain Gwen]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=759368 OS086_RS06175 WP_001186602.1 1191960..1193588(-) (ccrB) [Staphylococcus aureus strain Gwen]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

• Resolvase, N terminal domain (Resolvase) (11-156)

• Recombinase (Recombinase) (180-280)

3D structure

• AlphaFold DB: Q9XB94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	100	100	1