Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | OS092_RS13855 | Genome accession | NZ_CP113009 |
| Coordinates | 2695348..2696694 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain Orianna | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2646625..2696694 | 2695348..2696694 | within | 0 |
Gene organization within MGE regions
Location: 2646625..2696694
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OS092_RS13580 | ccrC | 2646625..2648310 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| OS092_RS13585 | tnpA | 2648358..2648843 (+) | 486 | WP_267810093.1 | IS200/IS605 family transposase | - |
| OS092_RS13590 | - | 2649135..2649473 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| OS092_RS13595 | - | 2649567..2649878 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| OS092_RS13600 | - | 2649894..2650400 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| OS092_RS13605 | - | 2650421..2650738 (+) | 318 | WP_023180038.1 | JAB domain-containing protein | - |
| OS092_RS13610 | - | 2650857..2651942 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| OS092_RS13615 | - | 2651939..2653831 (+) | 1893 | Protein_2645 | site-specific integrase | - |
| OS092_RS13620 | - | 2653838..2654215 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| OS092_RS13625 | - | 2654366..2655148 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| OS092_RS13630 | erm(A) | 2655274..2656005 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| OS092_RS15400 | - | 2656063..2656116 (-) | 54 | WP_178135703.1 | erythromycin resistance leader peptide | - |
| OS092_RS13635 | - | 2656508..2657170 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| OS092_RS15340 | - | 2657402..2657548 (+) | 147 | Protein_2651 | JAB domain-containing protein | - |
| OS092_RS13645 | - | 2657718..2658590 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| OS092_RS13650 | - | 2658647..2658937 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| OS092_RS13655 | - | 2658953..2659441 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| OS092_RS13660 | - | 2659576..2660103 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| OS092_RS13665 | - | 2660166..2660582 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| OS092_RS13670 | - | 2660871..2661035 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| OS092_RS13675 | - | 2661049..2661270 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| OS092_RS13680 | - | 2661420..2661986 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| OS092_RS13685 | - | 2662066..2664279 (-) | 2214 | Protein_2660 | type I restriction endonuclease subunit R | - |
| OS092_RS13690 | - | 2664341..2665015 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| OS092_RS13695 | - | 2665298..2666644 (+) | 1347 | WP_064221817.1 | dihydrolipoyl dehydrogenase family protein | - |
| OS092_RS13700 | merR | 2666944..2667351 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| OS092_RS13705 | - | 2667368..2667721 (+) | 354 | WP_000746201.1 | TlpA family protein disulfide reductase | - |
| OS092_RS13710 | - | 2667718..2668398 (+) | 681 | WP_000010352.1 | cytochrome c biogenesis CcdA family protein | - |
| OS092_RS13715 | merT | 2668486..2668872 (+) | 387 | WP_001794630.1 | mercuric transport protein MerT | - |
| OS092_RS13720 | merA | 2668930..2670573 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| OS092_RS13725 | merB | 2670655..2671305 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| OS092_RS13730 | - | 2671500..2672015 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| OS092_RS13735 | - | 2672134..2672808 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| OS092_RS13740 | - | 2672892..2673233 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| OS092_RS13745 | - | 2674270..2675013 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| OS092_RS13750 | - | 2675110..2675538 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| OS092_RS13755 | mecA | 2675584..2677593 (-) | 2010 | WP_267790023.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| OS092_RS13760 | mecR1 | 2677690..2679447 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| OS092_RS13765 | mecI | 2679447..2679818 (+) | 372 | Protein_2676 | mecA-type methicillin resistance repressor MecI | - |
| OS092_RS13770 | psm-mec | 2679903..2679971 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| OS092_RS13775 | - | 2680291..2681439 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| OS092_RS13780 | cstB | 2681553..2682887 (-) | 1335 | Protein_2679 | persulfide dioxygenase-sulfurtransferase CstB | - |
| OS092_RS13785 | - | 2682919..2683983 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| OS092_RS13790 | cstR | 2684119..2684379 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| OS092_RS13795 | - | 2684379..2685017 (+) | 639 | Protein_2682 | sulfite exporter TauE/SafE family protein | - |
| OS092_RS13800 | - | 2685291..2685908 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| OS092_RS13805 | - | 2685989..2688403 (-) | 2415 | WP_267835045.1 | cadmium-translocating P-type ATPase CadA | - |
| OS092_RS13810 | - | 2688396..2688761 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| OS092_RS13815 | - | 2688947..2689324 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| OS092_RS13820 | - | 2689331..2691223 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| OS092_RS13825 | - | 2691418..2691741 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| OS092_RS13830 | - | 2691734..2691940 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| OS092_RS13835 | - | 2691942..2692463 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| OS092_RS13840 | - | 2692482..2692793 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| OS092_RS13845 | - | 2692878..2693228 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| OS092_RS13850 | ccrB | 2693699..2695327 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| OS092_RS13855 | ccrA | 2695348..2696694 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=759042 OS092_RS13855 WP_000816499.1 2695348..2696694(-) (ccrA) [Staphylococcus aureus strain Orianna]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=759042 OS092_RS13855 WP_000816499.1 2695348..2696694(-) (ccrA) [Staphylococcus aureus strain Orianna]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |