Detailed information NTG0759031

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OS092_RS08420
• Genome accession: NZ_CP113009
• Coordinates: 1668018..1669061 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Orianna
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1663018..1674061

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OS092_RS08390	-	1663436..1664692 (-)	1257	WP_001795438.1	aminopeptidase	-
OS092_RS08395	-	1664695..1664895 (-)	201	WP_000180461.1	DUF1128 family protein	-
OS092_RS08400	-	1665042..1665506 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OS092_RS08405	-	1665513..1665788 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
OS092_RS08410	-	1666066..1667283 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
OS092_RS08415	vraR	1667399..1668028 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
OS092_RS08420	vraS	1668018..1669061 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OS092_RS08425	liaF	1669058..1669759 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OS092_RS08430	-	1669774..1670160 (-)	387	WP_001110179.1	hypothetical protein	-
OS092_RS08435	map	1670377..1671135 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OS092_RS08440	-	1671722..1672708 (+)	987	WP_000999713.1	FUSC family protein	-
OS092_RS08445	-	1673139..1673552 (-)	414	WP_001549145.1	hypothetical protein	-
OS092_RS08450	-	1673581..1673691 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=759031 OS092_RS08420 WP_001017131.1 1668018..1669061(-) (vraS) [Staphylococcus aureus strain Orianna]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=759031 OS092_RS08420 WP_001017131.1 1668018..1669061(-) (vraS) [Staphylococcus aureus strain Orianna]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1