Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   OS073_RS13190 Genome accession   NZ_CP113005
Coordinates   2524275..2525903 (-) Length   542 a.a.
NCBI ID   WP_001186596.1    Uniprot ID   -
Organism   Staphylococcus aureus strain Galio     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2474542..2527270 2524275..2525903 within 0


Gene organization within MGE regions


Location: 2474542..2527270
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS073_RS12905 ccrC 2474542..2476140 (+) 1599 Protein_2457 cassette chromosome recombinase CcrC -
  OS073_RS12910 tnpA 2476275..2476760 (+) 486 WP_267789991.1 IS200/IS605 family transposase -
  OS073_RS12915 - 2477052..2477390 (+) 339 WP_000175892.1 SAUGI family uracil-DNA glycosylase inhibitor -
  OS073_RS12920 - 2477484..2477795 (+) 312 WP_001166716.1 DUF960 family protein -
  OS073_RS12925 - 2477811..2478317 (+) 507 WP_000848380.1 DUF1643 domain-containing protein -
  OS073_RS12930 - 2478338..2478655 (+) 318 WP_023180038.1 JAB domain-containing protein -
  OS073_RS12935 - 2478774..2479859 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  OS073_RS12940 - 2479856..2481748 (+) 1893 Protein_2464 site-specific integrase -
  OS073_RS12945 - 2481755..2482132 (+) 378 WP_000361059.1 DUF6262 family protein -
  OS073_RS12950 - 2482283..2483065 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  OS073_RS12955 erm(A) 2483191..2483922 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  OS073_RS15685 - 2483980..2484033 (-) 54 WP_178135703.1 erythromycin resistance leader peptide -
  OS073_RS12960 - 2484425..2485087 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  OS073_RS12965 - 2485319..2485465 (+) 147 Protein_2470 JAB domain-containing protein -
  OS073_RS12970 - 2485635..2486507 (+) 873 WP_000373151.1 HTH domain-containing protein -
  OS073_RS12975 - 2486564..2486854 (+) 291 WP_000065262.1 hypothetical protein -
  OS073_RS12980 - 2486870..2487358 (+) 489 WP_000397419.1 hypothetical protein -
  OS073_RS12985 - 2487493..2488020 (+) 528 WP_000717928.1 hypothetical protein -
  OS073_RS12990 - 2488083..2488499 (+) 417 WP_000941331.1 hypothetical protein -
  OS073_RS12995 - 2488788..2488952 (+) 165 WP_001803222.1 hypothetical protein -
  OS073_RS13000 - 2488966..2489187 (+) 222 WP_001070883.1 hypothetical protein -
  OS073_RS13005 - 2489337..2489903 (+) 567 WP_000759939.1 PepSY domain-containing protein -
  OS073_RS13010 - 2489983..2491956 (-) 1974 Protein_2479 type I restriction endonuclease subunit R -
  OS073_RS13015 - 2491959..2492075 (+) 117 Protein_2480 protein rep -
  OS073_RS13020 - 2493057..2493638 (-) 582 WP_000991701.1 hypothetical protein -
  OS073_RS13025 - 2494090..2494842 (+) 753 Protein_2482 protein rep -
  OS073_RS13030 - 2494877..2495551 (-) 675 WP_001105999.1 IS6-like element IS257 family transposase -
  OS073_RS13035 - 2495834..2497180 (+) 1347 WP_064221817.1 dihydrolipoyl dehydrogenase family protein -
  OS073_RS13040 merR 2497480..2497887 (+) 408 WP_000425271.1 Hg(II)-responsive transcriptional regulator MerR -
  OS073_RS13045 - 2497904..2498257 (+) 354 WP_000746201.1 TlpA family protein disulfide reductase -
  OS073_RS13050 - 2498254..2498934 (+) 681 WP_000010352.1 cytochrome c biogenesis CcdA family protein -
  OS073_RS13055 merT 2499022..2499408 (+) 387 WP_001794630.1 mercuric transport protein MerT -
  OS073_RS13060 merA 2499466..2501109 (+) 1644 WP_000193219.1 mercury(II) reductase -
  OS073_RS13065 merB 2501191..2501841 (+) 651 WP_000790333.1 organomercurial lyase MerB -
  OS073_RS13070 - 2502036..2502551 (-) 516 WP_000377078.1 hypothetical protein -
  OS073_RS13075 - 2502670..2503344 (-) 675 WP_001105988.1 IS6-like element IS257 family transposase -
  OS073_RS13080 - 2503380..2503769 (+) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  OS073_RS13085 - 2504846..2505589 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  OS073_RS13090 - 2505686..2506114 (+) 429 WP_000872606.1 MaoC family dehydratase -
  OS073_RS13095 mecA 2506160..2508169 (-) 2010 WP_267790023.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  OS073_RS13100 mecR1 2508266..2510023 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  OS073_RS13105 mecI 2510023..2510394 (+) 372 Protein_2498 mecA-type methicillin resistance repressor MecI -
  OS073_RS13110 psm-mec 2510479..2510547 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  OS073_RS13115 - 2510867..2512015 (+) 1149 WP_000427807.1 ROK family transcriptional regulator -
  OS073_RS13120 cstB 2512129..2513463 (-) 1335 Protein_2501 persulfide dioxygenase-sulfurtransferase CstB -
  OS073_RS13125 - 2513495..2514559 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  OS073_RS13130 cstR 2514695..2514955 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  OS073_RS13135 - 2514955..2515593 (+) 639 Protein_2504 sulfite exporter TauE/SafE family protein -
  OS073_RS13140 - 2515867..2516484 (-) 618 WP_000562107.1 CadD family cadmium resistance transporter -
  OS073_RS13145 - 2516565..2518979 (-) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  OS073_RS13150 - 2518972..2519337 (-) 366 WP_000159127.1 ArsR/SmtB family transcription factor -
  OS073_RS13155 - 2519523..2519900 (-) 378 WP_001041908.1 DUF6262 family protein -
  OS073_RS13160 - 2519907..2521799 (-) 1893 WP_014532403.1 site-specific integrase -
  OS073_RS13165 - 2521994..2522317 (-) 324 WP_000088091.1 JAB domain-containing protein -
  OS073_RS13170 - 2522310..2522516 (-) 207 WP_001077283.1 hypothetical protein -
  OS073_RS13175 - 2522518..2523039 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  OS073_RS13180 - 2523058..2523369 (-) 312 WP_000833212.1 DUF960 family protein -
  OS073_RS13185 - 2523454..2523804 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  OS073_RS13190 ccrB 2524275..2525903 (-) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  OS073_RS13195 ccrA 2525924..2527270 (-) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62274.15 Da        Isoelectric Point: 9.7334

>NTDB_id=758951 OS073_RS13190 WP_001186596.1 2524275..2525903(-) (ccrB) [Staphylococcus aureus strain Galio]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=758951 OS073_RS13190 WP_001186596.1 2524275..2525903(-) (ccrB) [Staphylococcus aureus strain Galio]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAAAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

86.531

100

0.865