Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   UKS_RS09450 Genome accession   NZ_AP021887
Coordinates   1897024..1899456 (-) Length   810 a.a.
NCBI ID   WP_156012943.1    Uniprot ID   A0A6H3SN12
Organism   Streptococcus sp. 116-D4     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1892024..1904456
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UKS_RS09420 (UKS_18270) - 1892338..1892889 (+) 552 WP_156012933.1 cysteine hydrolase family protein -
  UKS_RS09425 (UKS_18280) - 1892959..1893672 (-) 714 WP_156012935.1 hypothetical protein -
  UKS_RS09430 - 1893951..1894181 (+) 231 Protein_1812 hypothetical protein -
  UKS_RS09435 (UKS_18300) - 1894254..1895027 (-) 774 WP_156012937.1 NUDIX hydrolase -
  UKS_RS09440 (UKS_18310) pnuC 1895029..1895808 (-) 780 WP_156012939.1 nicotinamide riboside transporter PnuC -
  UKS_RS09445 (UKS_18320) - 1895818..1896876 (-) 1059 WP_156012941.1 AAA family ATPase -
  UKS_RS09450 (UKS_18330) clpC 1897024..1899456 (-) 2433 WP_156012943.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  UKS_RS09455 (UKS_18340) - 1899458..1899916 (-) 459 WP_156012945.1 CtsR family transcriptional regulator -
  UKS_RS09460 (UKS_18350) - 1900035..1900763 (-) 729 WP_117304646.1 ABC transporter ATP-binding protein -
  UKS_RS09465 (UKS_18360) - 1900763..1901770 (-) 1008 WP_156012947.1 ABC transporter substrate-binding protein -
  UKS_RS09470 (UKS_18370) - 1901808..1902566 (-) 759 WP_173020487.1 ABC transporter permease -
  UKS_RS09475 (UKS_18380) - 1902529..1902819 (-) 291 WP_156012951.1 thiamine-binding protein -
  UKS_RS09480 (UKS_18390) cbpD 1903073..1904191 (-) 1119 WP_156012952.1 choline binding-anchored murein hydrolase CbpD -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90257.92 Da        Isoelectric Point: 5.7574

>NTDB_id=75388 UKS_RS09450 WP_156012943.1 1897024..1899456(-) (clpC) [Streptococcus sp. 116-D4]
MNYSKALNECIESAYMVASHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SHRLQVLFDEAEYVASVVHAKMLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTSSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIARGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMAILQGLKATYEKHHRVQITDDAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVTADDSGLSSADKALMDGKWKQAAQLIVKEEELPVYQDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGELEAGNTLKIGV
KAGQLKFDIV

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=75388 UKS_RS09450 WP_156012943.1 1897024..1899456(-) (clpC) [Streptococcus sp. 116-D4]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTGGCTAGCCATTTTGGAGCTCGTTATCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCCAATCACAGTTATAGTGTGGCCGGGGCGACTTTAAATGATTATCCATATGAGA
TGGACCGTTTAGAAGAGGTGGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTT
TCTCATCGTTTGCAGGTTCTTTTTGACGAAGCAGAGTATGTAGCATCAGTGGTCCATGCTAAGATGCTAGGGACAGAGCA
TGTCCTTTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCTCTTCGTCGAAATTTAGAAGAACGGGCAGGCTGGACTCGTGAAGACCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCGAATATGATGGGCATGCCCCAGACTTCAAGTGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAGCCAGTCATCGGTCGGGACAAGG
AAATCTCACGTATGATTCAAATCTTGAGTCGGAAGACCAAGAATAATCCTGTCTTGGTTGGGGATGCAGGTGTCGGGAAA
ACTGCTCTGGCGCTTGGTCTTGCTCAGCGTATTGCTAGAGGGGATGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGA
GCTTGATTTGATGAATGTTGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAACGCATGAACAATATCATAAAGGATA
TTGAAGAAGATGGCCAAGTCATCCTCTTTATCGATGAACTTCATACCATCATGGGTTCTGGTAGTGGAATTGACTCAACT
CTAGATGCGGCCAATATCTTGAAGCCAGCCTTGGCGCGTGGAACTTTGAGAACAGTTGGTGCCACCACTCAAGAAGAGTA
CCAAAAACACATTGAAAAAGATGCGGCCCTTTCTCGTCGATTCGCCAAAGTGACGATTGAAGAGCCAAGTGTGGCAGACA
GCATGGCCATTTTGCAAGGTTTGAAAGCGACCTATGAGAAGCATCATCGTGTGCAAATCACAGATGATGCGGTTGAAACA
GCTGTCAAGATGGCTCATCGTTACTTGACTAGTCGTCACTTGCCAGACTCCGCTATTGATCTTTTGGATGAGGCAGCAGC
AACAGTGCAAAATAAGGCTAAGCATGTAACAGCAGACGATTCTGGCTTGAGTTCAGCTGACAAGGCCTTGATGGATGGCA
AGTGGAAACAAGCAGCTCAGCTAATCGTAAAAGAAGAGGAATTGCCTGTCTATCAAGACTTGGTAACAGAGTCTGATATT
TTGACCACCTTAAGTCGCTTGTCAGGTATTCCAGTCCAAAAACTGACTCAGACTGATGCTAAGAAATACTTAAACTTGGA
AGCTGAACTGCACAAACGTGTCATCGGTCAAGATCAAGCTGTTTCAAGTATTAGCCGTGCCATTCGCCGCAACCAGTCAG
GGATTCGCAGTCATAAGCGTCCTATTGGTTCCTTTATGTTCTTAGGGCCTACAGGTGTCGGGAAGACTGAATTGGCCAAG
GCTCTGGCAGAAGTTCTTTTTGACGACGAATCAGCTCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTCGCAGC
CAGCCGTCTCAATGGAGCTCCTCCGGGTTATGTTGGTTACGAAGAAGGTGGGGAGTTGACCGAGAAGGTTCGCAATAAAC
CATACTCTGTTCTCCTCTTTGACGAGGTAGAAAAGGCCCACCCAGACATCTTTAATGTGCTCTTGCAGGTCTTGGATGAC
GGTGTCTTGACCGATAGCAAGGGCCGCAAGGTTGACTTTTCAAATACCATTATCATCATGACGTCAAACCTTGGTGCGAC
AGCCCTTCGGGATGACAAGACAGTTGGATTTGGGGCAAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAGCTGAAAAAAGCTTATAGACCTGAGTTTATCAACCGTATTGATGAAAAGGTGGTCTTCCATAGCCTTTCTAGC
GATCATATGCAGGAAGTGGTGAAGATTATGGTCAAACCTTTAGTGGCAAGTTTGGCTGAAAAAGGCATTGACTTGAAATT
ACAAGCTTCCGCACTGAAATTGTTGGCCAATCAAGGATATGACCCAGAGATGGGAGCTCGTCCGCTTCGCAGAACCCTAC
AAACAGAAGTGGAAGACAAGTTGGCAGAACTTCTTCTCAAGGGAGAATTAGAGGCAGGCAACACACTTAAGATTGGTGTT
AAAGCAGGCCAGTTAAAATTTGATATTGTATAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(370-439)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(102-139)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(14-49)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6H3SN12

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae D39

97.775

99.877

0.977
  clpC Streptococcus pneumoniae TIGR4

97.775

99.877

0.977
  clpC Streptococcus pneumoniae Rx1

97.775

99.877

0.977
  clpC Streptococcus mutans UA159

66.953

100

0.673
  clpC Streptococcus thermophilus LMD-9

65.767

100

0.662
  clpC Streptococcus thermophilus LMG 18311

65.644

100

0.66
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

49.212

100

0.501
  clpC Bacillus subtilis subsp. subtilis str. 168

44.951

100

0.451
  clpE Streptococcus mutans UA159

47.756

77.037

0.368

Multiple sequence alignment