Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | NT398_RS10340 | Genome accession | NZ_CP109933 |
| Coordinates | 2059839..2061188 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain SASWT1215 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2024335..2068059 | 2059839..2061188 | within | 0 |
| SCCmec | 2059839..2081179 | 2059839..2061188 | within | 0 |
Gene organization within MGE regions
Location: 2024335..2081179
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NT398_RS10195 (NT398_10200) | - | 2024335..2027487 (-) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
| NT398_RS10200 (NT398_10205) | - | 2027754..2028356 (-) | 603 | WP_000908956.1 | hypothetical protein | - |
| NT398_RS10205 (NT398_10210) | - | 2028564..2028860 (-) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| NT398_RS10210 (NT398_10215) | - | 2028909..2029112 (-) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| NT398_RS10215 (NT398_10220) | - | 2029421..2030407 (+) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| NT398_RS14875 | - | 2030593..2030807 (+) | 215 | Protein_1981 | universal stress protein | - |
| NT398_RS10220 (NT398_10225) | sqr | 2031074..2032267 (-) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| NT398_RS10225 (NT398_10230) | cstB | 2032286..2033620 (-) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| NT398_RS10230 (NT398_10235) | cstA | 2033651..2034715 (-) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| NT398_RS10235 (NT398_10240) | cstR | 2034852..2035112 (+) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| NT398_RS10240 (NT398_10245) | - | 2035112..2035867 (+) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| NT398_RS10245 (NT398_10250) | - | 2035965..2036053 (+) | 89 | Protein_1987 | hypothetical protein | - |
| NT398_RS10250 (NT398_10255) | - | 2036358..2036713 (+) | 356 | Protein_1988 | tRNA-dihydrouridine synthase | - |
| NT398_RS10255 (NT398_10260) | - | 2036811..2038556 (-) | 1746 | WP_063653119.1 | DUF6119 family protein | - |
| NT398_RS10260 (NT398_10265) | - | 2038703..2038795 (-) | 93 | WP_001790000.1 | hypothetical protein | - |
| NT398_RS10265 (NT398_10270) | - | 2038759..2038893 (+) | 135 | WP_001790628.1 | hypothetical protein | - |
| NT398_RS10270 (NT398_10275) | - | 2039143..2040651 (-) | 1509 | WP_001001347.1 | protein kinase | - |
| NT398_RS10275 (NT398_10280) | - | 2040766..2041392 (+) | 627 | WP_001176969.1 | hypothetical protein | - |
| NT398_RS10280 (NT398_10285) | - | 2042511..2043407 (+) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| NT398_RS10285 (NT398_10290) | - | 2043417..2044286 (+) | 870 | WP_000626133.1 | hypothetical protein | - |
| NT398_RS10290 (NT398_10295) | - | 2044831..2045387 (-) | 557 | Protein_1996 | K(+)-transporting ATPase subunit C | - |
| NT398_RS10295 (NT398_10300) | - | 2045403..2047424 (-) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| NT398_RS10300 (NT398_10305) | kdpA | 2047443..2049119 (-) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| NT398_RS14880 | kdpF | 2049140..2049220 (-) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| NT398_RS10305 (NT398_10310) | - | 2049387..2052056 (+) | 2670 | WP_000446429.1 | sensor histidine kinase KdpD | - |
| NT398_RS10310 (NT398_10315) | - | 2052031..2052726 (+) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| NT398_RS10315 (NT398_10320) | - | 2053448..2054374 (+) | 927 | Protein_2002 | YfcC family protein | - |
| NT398_RS10320 (NT398_10325) | - | 2054885..2056026 (+) | 1142 | Protein_2003 | IS3-like element ISSau4 family transposase | - |
| NT398_RS10325 (NT398_10330) | - | 2056277..2057323 (+) | 1047 | WP_001060127.1 | hypothetical protein | - |
| NT398_RS10330 (NT398_10335) | - | 2057516..2057812 (+) | 297 | WP_000273824.1 | single-stranded DNA-binding protein | - |
| NT398_RS10335 (NT398_10340) | - | 2057812..2059605 (+) | 1794 | WP_000195100.1 | DUF927 domain-containing protein | - |
| NT398_RS10340 (NT398_10345) | ccrA | 2059839..2061188 (+) | 1350 | WP_000815646.1 | recombinase family protein | Machinery gene |
| NT398_RS10345 (NT398_10350) | ccrB | 2061210..2062838 (+) | 1629 | WP_001186602.1 | recombinase family protein | Machinery gene |
| NT398_RS10350 (NT398_10355) | - | 2063356..2063706 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| NT398_RS10355 (NT398_10360) | - | 2063793..2064104 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| NT398_RS10360 (NT398_10365) | - | 2064122..2064628 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| NT398_RS10365 (NT398_10370) | - | 2064649..2064966 (+) | 318 | WP_061641403.1 | JAB domain-containing protein | - |
| NT398_RS10370 (NT398_10375) | - | 2065085..2066170 (+) | 1086 | WP_284590341.1 | tyrosine-type recombinase/integrase | - |
| NT398_RS10375 (NT398_10380) | - | 2066167..2068059 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| NT398_RS10380 (NT398_10385) | - | 2068066..2068443 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| NT398_RS10385 (NT398_10390) | - | 2068594..2069376 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| NT398_RS10390 (NT398_10395) | erm(A) | 2069502..2070233 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| NT398_RS14885 | - | 2070291..2070350 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| NT398_RS10395 (NT398_10400) | - | 2070742..2071404 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| NT398_RS10400 (NT398_10405) | - | 2071749..2072387 (-) | 639 | Protein_2020 | sulfite exporter TauE/SafE family protein | - |
| NT398_RS10405 (NT398_10410) | cstR | 2072387..2072647 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| NT398_RS10410 (NT398_10415) | - | 2072783..2073847 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| NT398_RS10415 (NT398_10420) | cstB | 2073880..2075214 (+) | 1335 | Protein_2023 | persulfide dioxygenase-sulfurtransferase CstB | - |
| NT398_RS10420 (NT398_10425) | - | 2075328..2076437 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| NT398_RS10425 (NT398_10430) | psm-mec | 2076792..2076860 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| NT398_RS10430 (NT398_10435) | mecI | 2076945..2077316 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| NT398_RS10435 (NT398_10440) | mecR1 | 2077316..2079073 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| NT398_RS10440 (NT398_10445) | mecA | 2079170..2081179 (+) | 2010 | WP_217654299.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=750834 NT398_RS10340 WP_000815646.1 2059839..2061188(+) (ccrA) [Staphylococcus aureus strain SASWT1215]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=750834 NT398_RS10340 WP_000815646.1 2059839..2061188(+) (ccrA) [Staphylococcus aureus strain SASWT1215]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |