Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | MRSL_RS00400 | Genome accession | NZ_AP021848 |
| Coordinates | 85545..87173 (-) | Length | 542 a.a. |
| NCBI ID | WP_172412330.1 | Uniprot ID | - |
| Organism | Staphylococcus lugdunensis strain JICS135 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 55252..106129 | 85545..87173 | within | 0 |
Gene organization within MGE regions
Location: 55252..106129
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MRSL_RS00265 (MRSL_00520) | mecA | 55252..57261 (-) | 2010 | WP_063852638.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| MRSL_RS00270 | - | 57358..57465 (+) | 108 | Protein_51 | beta-lactam sensor/signal transducer MecR1 | - |
| MRSL_RS00275 | - | 57506..58180 (+) | 675 | Protein_52 | IS6 family transposase | - |
| MRSL_RS00280 (MRSL_00550) | - | 58240..58668 (-) | 429 | WP_000671997.1 | VOC family protein | - |
| MRSL_RS00285 (MRSL_00560) | - | 58749..59678 (+) | 930 | WP_000750311.1 | helix-turn-helix transcriptional regulator | - |
| MRSL_RS00290 (MRSL_00570) | - | 59840..61852 (+) | 2013 | WP_002437507.1 | hypothetical protein | - |
| MRSL_RS00295 (MRSL_00580) | - | 62022..63131 (+) | 1110 | WP_172412327.1 | DNA polymerase | - |
| MRSL_RS00300 (MRSL_00590) | - | 63124..63495 (+) | 372 | WP_124726190.1 | hypothetical protein | - |
| MRSL_RS00305 (MRSL_00600) | - | 63492..65111 (+) | 1620 | WP_172412328.1 | DUF5906 domain-containing protein | - |
| MRSL_RS00310 (MRSL_00610) | ccrC | 65337..67016 (+) | 1680 | WP_172412329.1 | cassette chromosome recombinase CcrC | - |
| MRSL_RS00315 (MRSL_00620) | - | 67105..67443 (+) | 339 | WP_031796882.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MRSL_RS00320 (MRSL_00630) | - | 67537..67848 (+) | 312 | WP_168754273.1 | DUF960 family protein | - |
| MRSL_RS00325 (MRSL_00640) | - | 67866..68369 (+) | 504 | WP_168754274.1 | DUF1643 domain-containing protein | - |
| MRSL_RS00330 (MRSL_00650) | - | 68383..68604 (+) | 222 | WP_168754275.1 | hypothetical protein | - |
| MRSL_RS00335 (MRSL_00660) | - | 68683..70950 (-) | 2268 | WP_168754276.1 | CDP-glycerol:glycerophosphate glycerophosphotransferase | - |
| MRSL_RS00340 (MRSL_00670) | - | 71207..71389 (+) | 183 | WP_031864945.1 | hypothetical protein | - |
| MRSL_RS00345 (MRSL_00680) | - | 72431..72731 (-) | 301 | Protein_66 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| MRSL_RS00350 (MRSL_00690) | - | 72913..73782 (+) | 870 | WP_168754285.1 | hypothetical protein | - |
| MRSL_RS00355 (MRSL_00700) | - | 73954..75126 (+) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| MRSL_RS00360 (MRSL_00710) | - | 75517..75750 (-) | 234 | WP_002467980.1 | hypothetical protein | - |
| MRSL_RS00365 (MRSL_00720) | - | 75974..77146 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| MRSL_RS00370 (MRSL_00730) | - | 77322..80666 (+) | 3345 | WP_058649859.1 | SdrD B-like domain-containing protein | - |
| MRSL_RS00375 (MRSL_00740) | gtfA | 80755..82263 (+) | 1509 | WP_001551920.1 | accessory Sec system glycosyltransferase GtfA | - |
| MRSL_RS00380 (MRSL_00750) | gtfB | 82256..83575 (+) | 1320 | WP_002468074.1 | accessory Sec system glycosylation chaperone GtfB | - |
| MRSL_RS00385 (MRSL_00760) | - | 83756..84259 (-) | 504 | WP_058649860.1 | DUF1643 domain-containing protein | - |
| MRSL_RS00390 (MRSL_00770) | - | 84274..84588 (-) | 315 | WP_058649861.1 | DUF960 family protein | - |
| MRSL_RS00395 (MRSL_00780) | - | 84681..85022 (-) | 342 | WP_058649862.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MRSL_RS00400 (MRSL_00790) | ccrB | 85545..87173 (-) | 1629 | WP_172412330.1 | cassette chromosome recombinase CcrB | Machinery gene |
| MRSL_RS00405 (MRSL_00800) | ccrA | 87195..88544 (-) | 1350 | WP_001573628.1 | cassette chromosome recombinase CcrA | Machinery gene |
| MRSL_RS00410 (MRSL_00810) | cch1 | 88778..90565 (-) | 1788 | WP_058649864.1 | cassette chromosome replicative helicase | - |
| MRSL_RS00415 (MRSL_00820) | ssb | 90565..90861 (-) | 297 | WP_002454339.1 | cassette chromosome ssDNA-binding protein | - |
| MRSL_RS00420 (MRSL_00830) | - | 91054..92100 (-) | 1047 | WP_001042023.1 | hypothetical protein | - |
| MRSL_RS00425 (MRSL_00840) | - | 92555..93709 (+) | 1155 | WP_000912116.1 | ATP-binding protein | - |
| MRSL_RS00430 (MRSL_00850) | - | 93739..94539 (+) | 801 | WP_058649865.1 | abortive infection family protein | - |
| MRSL_RS00435 (MRSL_00870) | - | 94695..95836 (+) | 1142 | WP_094449189.1 | IS3 family transposase | - |
| MRSL_RS00440 (MRSL_00880) | - | 96279..99308 (-) | 3030 | WP_058649866.1 | type I restriction endonuclease subunit R | - |
| MRSL_RS00445 (MRSL_00890) | - | 99321..100559 (-) | 1239 | WP_228279883.1 | restriction endonuclease subunit S | - |
| MRSL_RS00450 (MRSL_00900) | - | 100552..102339 (-) | 1788 | WP_058649867.1 | type I restriction-modification system subunit M | - |
| MRSL_RS00455 (MRSL_00910) | - | 102482..102703 (-) | 222 | WP_058649868.1 | hypothetical protein | - |
| MRSL_RS00460 (MRSL_00920) | - | 102717..103220 (-) | 504 | WP_058649869.1 | DUF1643 domain-containing protein | - |
| MRSL_RS00465 (MRSL_00930) | - | 103235..103546 (-) | 312 | WP_058649870.1 | DUF960 family protein | - |
| MRSL_RS00470 (MRSL_00940) | - | 103633..103983 (-) | 351 | WP_058649871.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MRSL_RS00475 (MRSL_00950) | ccrB | 104504..106129 (-) | 1626 | WP_058649872.1 | cassette chromosome recombinase CcrB | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62660.88 Da Isoelectric Point: 9.8616
>NTDB_id=74973 MRSL_RS00400 WP_172412330.1 85545..87173(-) (ccrB) [Staphylococcus lugdunensis strain JICS135]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKDGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADAIEDYVMKQILEIVKSDKVIQQVVARVNQENQVDCASLHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKKLNDITNQINQLKNQQNEDMTLFNAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKHFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKDGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADAIEDYVMKQILEIVKSDKVIQQVVARVNQENQVDCASLHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKKLNDITNQINQLKNQQNEDMTLFNAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKHFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=74973 MRSL_RS00400 WP_172412330.1 85545..87173(-) (ccrB) [Staphylococcus lugdunensis strain JICS135]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGATGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGTAAC
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACACGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGACATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCTCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACCAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGCTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGCGATTGAAGATTATGTGATGAAGCAAATACTCGAAATAGTCAAAAGTGATAAAGTCATTCAACAGGTTG
TAGCACGTGTTAATCAAGAAAATCAAGTTGATTGTGCGTCACTTCATCACGATATCGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGAAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATATGACTT
TATTTAATGCCAAAGAAATTAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACATTTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGATGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGTAAC
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACACGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGACATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCTCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACCAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGCTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGCGATTGAAGATTATGTGATGAAGCAAATACTCGAAATAGTCAAAAGTGATAAAGTCATTCAACAGGTTG
TAGCACGTGTTAATCAAGAAAATCAAGTTGATTGTGCGTCACTTCATCACGATATCGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGAAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATATGACTT
TATTTAATGCCAAAGAAATTAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACATTTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
97.786 |
100 |
0.978 |