Detailed information NTG0074827

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KUH140013_RS00475
• Genome accession: NZ_AP020324
• Coordinates: 82908..83951 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KUN1163
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77908..88951

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KUH140013_RS00445	-	78334..78444 (+)	111	WP_001790257.1	hypothetical protein	-
KUH140013_RS00450 (KUN1163_0076)	-	78473..78886 (+)	414	WP_001557448.1	hypothetical protein	-
KUH140013_RS00455 (KUN1163_0077)	-	79317..80303 (-)	987	WP_000999717.1	FUSC family protein	-
KUH140013_RS00460 (KUN1163_0078)	map	80834..81592 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KUH140013_RS00465 (KUN1163_0079)	-	81809..82195 (+)	387	WP_001110179.1	hypothetical protein	-
KUH140013_RS00470 (KUN1163_0080)	liaF	82210..82911 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KUH140013_RS00475 (KUN1163_0081)	vraS	82908..83951 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KUH140013_RS00480 (KUN1163_0082)	vraR	83941..84570 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KUH140013_RS00485 (KUN1163_0083)	-	84683..85900 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KUH140013_RS00490 (KUN1163_0084)	-	86178..86453 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KUH140013_RS00495 (KUN1163_0085)	-	86460..86924 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KUH140013_RS00500 (KUN1163_0086)	-	87071..87271 (+)	201	WP_000180460.1	DUF1128 family protein	-
KUH140013_RS00505 (KUN1163_0087)	-	87274..88530 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=74827 KUH140013_RS00475 WP_001017131.1 82908..83951(+) (vraS) [Staphylococcus aureus strain KUN1163]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=74827 KUH140013_RS00475 WP_001017131.1 82908..83951(+) (vraS) [Staphylococcus aureus strain KUN1163]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1