Detailed information NTG0074786

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: F6Y14_RS00490
• Genome accession: NZ_AP020322
• Coordinates: 82901..83944 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KUH180129
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77901..88944

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F6Y14_RS00460	-	78328..78437 (+)	110	Protein_87	hypothetical protein	-
F6Y14_RS00465 (KUH180129_0077)	-	78466..78879 (+)	414	WP_001557448.1	hypothetical protein	-
F6Y14_RS00470 (KUH180129_0078)	-	79310..80296 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
F6Y14_RS00475 (KUH180129_0079)	map	80827..81585 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
F6Y14_RS00480 (KUH180129_0080)	-	81802..82188 (+)	387	WP_001110179.1	hypothetical protein	-
F6Y14_RS00485 (KUH180129_0081)	liaF	82203..82904 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
F6Y14_RS00490 (KUH180129_0082)	vraS	82901..83944 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
F6Y14_RS00495 (KUH180129_0083)	vraR	83934..84563 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
F6Y14_RS00500 (KUH180129_0084)	-	84676..85893 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
F6Y14_RS00505 (KUH180129_0085)	-	86171..86446 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
F6Y14_RS00510 (KUH180129_0086)	-	86453..86917 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
F6Y14_RS00515 (KUH180129_0087)	-	87064..87264 (+)	201	WP_000180460.1	DUF1128 family protein	-
F6Y14_RS00520 (KUH180129_0088)	-	87267..88523 (+)	1257	WP_150073877.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=74786 F6Y14_RS00490 WP_001017131.1 82901..83944(+) (vraS) [Staphylococcus aureus strain KUH180129]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=74786 F6Y14_RS00490 WP_001017131.1 82901..83944(+) (vraS) [Staphylococcus aureus strain KUH180129]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1