Detailed information NTG0074612

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: F6Y15_RS00595
• Genome accession: NZ_AP020313
• Coordinates: 105841..106884 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KUH140046
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 100841..111884

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F6Y15_RS00565	-	101211..101321 (+)	111	WP_001790257.1	hypothetical protein	-
F6Y15_RS00570 (KUH140046_0100)	-	101350..101763 (+)	414	WP_001549145.1	hypothetical protein	-
F6Y15_RS00575 (KUH140046_0101)	-	102194..103180 (-)	987	WP_000999713.1	FUSC family protein	-
F6Y15_RS00580 (KUH140046_0102)	map	103767..104525 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
F6Y15_RS00585 (KUH140046_0103)	-	104742..105128 (+)	387	WP_001110179.1	hypothetical protein	-
F6Y15_RS00590 (KUH140046_0104)	liaF	105143..105844 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
F6Y15_RS00595 (KUH140046_0105)	vraS	105841..106884 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
F6Y15_RS00600 (KUH140046_0106)	vraR	106874..107503 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
F6Y15_RS00605 (KUH140046_0107)	-	107619..108836 (-)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
F6Y15_RS00610 (KUH140046_0108)	-	109114..109389 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
F6Y15_RS00615 (KUH140046_0109)	-	109396..109860 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
F6Y15_RS00620 (KUH140046_0110)	-	110007..110207 (+)	201	WP_000180461.1	DUF1128 family protein	-
F6Y15_RS00625 (KUH140046_0111)	-	110210..111466 (+)	1257	WP_108932452.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=74612 F6Y15_RS00595 WP_001017131.1 105841..106884(+) (vraS) [Staphylococcus aureus strain KUH140046]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=74612 F6Y15_RS00595 WP_001017131.1 105841..106884(+) (vraS) [Staphylococcus aureus strain KUH140046]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1