Detailed information NTG0074569

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: F6Y13_RS00520
• Genome accession: NZ_AP020311
• Coordinates: 91702..92745 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KUH140013
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86702..97745

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F6Y13_RS00485	-	87013..87123 (+)	111	WP_001790257.1	hypothetical protein	-
F6Y13_RS00490 (KUH140013_0082)	-	87152..87565 (+)	414	WP_001549145.1	hypothetical protein	-
F6Y13_RS00500 (KUH140013_0083)	-	88055..89041 (-)	987	WP_000999713.1	FUSC family protein	-
F6Y13_RS00505 (KUH140013_0084)	map	89628..90386 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
F6Y13_RS00510 (KUH140013_0085)	-	90603..90989 (+)	387	WP_001110179.1	hypothetical protein	-
F6Y13_RS00515 (KUH140013_0086)	liaF	91004..91705 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
F6Y13_RS00520 (KUH140013_0087)	vraS	91702..92745 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
F6Y13_RS00525 (KUH140013_0088)	vraR	92735..93364 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
F6Y13_RS00530 (KUH140013_0089)	-	93480..94697 (-)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
F6Y13_RS00535 (KUH140013_0090)	-	94975..95250 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
F6Y13_RS00540 (KUH140013_0091)	-	95257..95721 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
F6Y13_RS00545 (KUH140013_0092)	-	95868..96068 (+)	201	WP_000180461.1	DUF1128 family protein	-
F6Y13_RS00550 (KUH140013_0093)	-	96071..97327 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=74569 F6Y13_RS00520 WP_001017131.1 91702..92745(+) (vraS) [Staphylococcus aureus strain KUH140013]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=74569 F6Y13_RS00520 WP_001017131.1 91702..92745(+) (vraS) [Staphylococcus aureus strain KUH140013]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1