Detailed information NTG0074552

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: SAGCMC97051_RS05635
• Genome accession: NZ_AP020310
• Coordinates: 1056263..1057576 (-)
• Length: 437 a.a.
• NCBI ID: WP_000042580.1
• Uniprot ID: A0AAW3HV66
• Organism: Streptococcus agalactiae strain GCMC97051
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1053665..1056124	1056263..1057576	flank	139

Gene organization within MGE regions

Location: 1053665..1057576

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAGCMC97051_RS05625 (SAGCMC97051_10340)	-	1053665..1054798 (-)	1134	WP_000564846.1	ISAs1-like element IS1548 family transposase	-
SAGCMC97051_RS05630 (SAGCMC97051_10350)	-	1054991..1056124 (-)	1134	WP_000564846.1	ISAs1-like element IS1548 family transposase	-
SAGCMC97051_RS05635 (SAGCMC97051_10360)	ciaH	1056263..1057576 (-)	1314	WP_000042580.1	sensor histidine kinase	Regulator

Sequence

Protein

• Length: 437 a.a.
• Molecular weight: 49708.14 Da
• Isoelectric Point: 9.4961

>NTDB_id=74552 SAGCMC97051_RS05635 WP_000042580.1 1056263..1057576(-) (ciaH) [Streptococcus agalactiae strain GCMC97051]
MSKPIKISKFKKNVSDSHFIHFFTVFSGIFLVMTVIILQVMRYGVYSSVDSSLKYISTHPKNYINMVMSRTAAYLDNSNI
ASVKLKPGGQTVANTDIILFTSEEEVINYFDAFSNYQFLKPNKKNLGGISELTLTNIFGQDETYHAVTVKVNNPAYPNVT
YMTAIVNIDQLVNAKERYEKIIIFVMTTFWIISIGASIYLAKWAQKPIIENYERQKAFVENASHELRTPLAVLQNRLETL
FRKPNATILENSENIASSLDEVRNMRILTTNLLNLARRDDGIKPELAVIKPTLFDSIFENYDLITQENGKNFTGHNMIQD
SFKTDKTLLKQLMTILFDNAIKYTDNDGSIDFTISETDKYLFLEIADNGPGISEEDKVRIFDRFYRVDKARTRQQGGFGL
GLSLAQQIVNSLRGNITVIDNKPRGSIFKIKLPKVKG

Nucleotide

• Length: 1314 bp

>NTDB_id=74552 SAGCMC97051_RS05635 WP_000042580.1 1056263..1057576(-) (ciaH) [Streptococcus agalactiae strain GCMC97051]
ATGTCGAAACCGATTAAGATAAGTAAATTCAAAAAAAATGTCTCAGATAGTCATTTTATCCATTTTTTCACAGTTTTTAG
TGGTATTTTTCTGGTTATGACTGTTATCATCCTCCAAGTCATGCGCTATGGTGTTTATTCTTCTGTTGATAGTAGTTTAA
AGTATATCAGTACCCATCCTAAAAATTACATCAATATGGTTATGTCACGTACTGCTGCCTACCTAGATAACTCCAATATC
GCAAGTGTCAAGTTAAAACCCGGCGGTCAGACAGTAGCTAATACTGATATTATTCTTTTTACATCAGAAGAAGAAGTCAT
TAACTATTTTGACGCATTTTCAAACTATCAGTTTTTAAAACCTAATAAAAAAAATCTAGGTGGCATTAGTGAATTAACTT
TAACCAACATCTTTGGTCAAGATGAGACATATCATGCTGTCACCGTAAAAGTTAATAACCCTGCTTATCCTAATGTGACT
TACATGACAGCTATTGTTAATATTGATCAATTAGTAAATGCTAAAGAACGCTATGAAAAAATTATTATATTTGTCATGAC
TACTTTTTGGATTATTTCAATTGGAGCAAGTATCTACTTAGCTAAATGGGCACAAAAACCGATTATAGAAAACTACGAAA
GACAGAAGGCTTTTGTCGAAAATGCTAGCCACGAGCTGCGTACTCCCCTAGCTGTCTTACAAAATCGCCTAGAAACGCTA
TTCAGAAAACCGAATGCCACCATTTTAGAAAATAGTGAAAATATCGCTTCAAGTCTAGATGAAGTACGAAATATGCGTAT
TTTAACCACTAATCTTTTAAACTTAGCAAGACGTGATGATGGAATCAAACCAGAATTAGCTGTTATTAAGCCTACACTTT
TTGATAGTATCTTTGAGAATTATGATCTAATCACCCAAGAGAATGGTAAAAATTTTACTGGACATAATATGATCCAAGAT
AGTTTCAAAACAGATAAGACACTGCTAAAACAACTCATGACTATTTTATTTGATAATGCTATAAAATATACTGACAATGA
TGGTAGCATTGACTTTACCATATCTGAAACTGATAAGTATCTCTTTTTAGAAATCGCTGATAATGGACCAGGAATTTCAG
AGGAGGATAAAGTCAGAATTTTTGATCGTTTTTACCGTGTTGACAAAGCAAGAACACGACAACAAGGAGGGTTTGGCCTC
GGCCTTTCTTTAGCTCAACAAATCGTTAACTCACTGCGAGGTAATATTACAGTAATTGATAATAAACCTAGAGGCAGTAT
TTTTAAGATAAAACTACCAAAAGTAAAAGGTTAG

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (325-434)

• His Kinase A (phospho-acceptor) domain (HisKA) (216-281)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	60.14	98.169	0.59
ciaH	Streptococcus pneumoniae Rx1	51.781	96.339	0.499
ciaH	Streptococcus pneumoniae D39	51.781	96.339	0.499
ciaH	Streptococcus pneumoniae R6	51.781	96.339	0.499
ciaH	Streptococcus pneumoniae TIGR4	51.781	96.339	0.499