Detailed information NTG0735986

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: N8145_RS04225
• Genome accession: NZ_CP106834
• Coordinates: 900274..901320 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain AH6072
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 895274..906320

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
N8145_RS04200 (N8145_04200)	isaB	896415..896951 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
N8145_RS04205 (N8145_04205)	-	897102..898088 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
N8145_RS04210 (N8145_04210)	map	898262..899017 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
N8145_RS04215 (N8145_04215)	-	899175..899561 (+)	387	WP_001830382.1	hypothetical protein	-
N8145_RS04220 (N8145_04220)	liaF	899576..900277 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
N8145_RS04225 (N8145_04225)	vraS	900274..901320 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
N8145_RS04230 (N8145_04230)	vraR	901310..901939 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
N8145_RS04235 (N8145_04235)	-	901996..903174 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
N8145_RS04240 (N8145_04240)	-	903581..903865 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
N8145_RS04245 (N8145_04245)	-	903873..904337 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
N8145_RS04250 (N8145_04250)	-	904478..904693 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
N8145_RS04255 (N8145_04255)	-	904695..905936 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=735986 N8145_RS04225 WP_001830374.1 900274..901320(+) (vraS) [Staphylococcus epidermidis strain AH6072]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=735986 N8145_RS04225 WP_001830374.1 900274..901320(+) (vraS) [Staphylococcus epidermidis strain AH6072]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92