Detailed information NTG0073574

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FNL83_RS04675
• Genome accession: NZ_AP019721
• Coordinates: 950819..951865 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain NBRC 100911
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 945819..956865

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FNL83_RS04650 (Sep02g_08790)	isaB	946960..947496 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
FNL83_RS04655 (Sep02g_08800)	-	947647..948633 (-)	987	WP_002457091.1	FUSC family protein	-
FNL83_RS04660 (Sep02g_08810)	map	948807..949562 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
FNL83_RS04665 (Sep02g_08820)	-	949720..950106 (+)	387	WP_002489903.1	hypothetical protein	-
FNL83_RS04670 (Sep02g_08830)	liaF	950121..950822 (+)	702	WP_002473931.1	cell wall-active antibiotics response protein LiaF	-
FNL83_RS04675 (Sep02g_08840)	vraS	950819..951865 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
FNL83_RS04680 (Sep02g_08850)	vraR	951855..952484 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
FNL83_RS04685 (Sep02g_08860)	-	952541..953719 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
FNL83_RS04690 (Sep02g_08870)	-	954126..954410 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
FNL83_RS04695 (Sep02g_08880)	-	954418..954882 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
FNL83_RS04700 (Sep02g_08890)	-	955023..955238 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
FNL83_RS04705 (Sep02g_08900)	-	955240..956481 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=73574 FNL83_RS04675 WP_001830374.1 950819..951865(+) (vraS) [Staphylococcus epidermidis strain NBRC 100911]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=73574 FNL83_RS04675 WP_001830374.1 950819..951865(+) (vraS) [Staphylococcus epidermidis strain NBRC 100911]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTTAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTGTTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCATTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92