Detailed information NTG0072830

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GDK20_RS10275
• Genome accession: NZ_AP019545
• Coordinates: 2048311..2049354 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KG-22
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2043311..2054354

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GDK20_RS10245 (SAKG22_18800)	-	2043732..2044988 (-)	1257	WP_001795108.1	aminopeptidase	-
GDK20_RS10250 (SAKG22_18810)	-	2044991..2045191 (-)	201	WP_000180460.1	DUF1128 family protein	-
GDK20_RS10255 (SAKG22_18820)	-	2045338..2045802 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
GDK20_RS10260 (SAKG22_18830)	-	2045809..2046084 (+)	276	WP_117195002.1	YtxH domain-containing protein	-
GDK20_RS10265 (SAKG22_18840)	-	2046362..2047579 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
GDK20_RS10270 (SAKG22_18850)	vraR	2047692..2048321 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
GDK20_RS10275 (SAKG22_18860)	vraS	2048311..2049354 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
GDK20_RS10280 (SAKG22_18870)	liaF	2049351..2050052 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
GDK20_RS10285 (SAKG22_18880)	-	2050067..2050453 (-)	387	WP_001110179.1	hypothetical protein	-
GDK20_RS10290 (SAKG22_18890)	map	2050670..2051428 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
GDK20_RS10295 (SAKG22_18900)	-	2051959..2052945 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
GDK20_RS10300 (SAKG22_18910)	-	2053376..2053789 (-)	414	WP_001557448.1	hypothetical protein	-
GDK20_RS10305	-	2053818..2053928 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=72830 GDK20_RS10275 WP_001017131.1 2048311..2049354(-) (vraS) [Staphylococcus aureus strain KG-22]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=72830 GDK20_RS10275 WP_001017131.1 2048311..2049354(-) (vraS) [Staphylococcus aureus strain KG-22]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1