Detailed information NTG0072788

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GDK18_RS10275
• Genome accession: NZ_AP019543
• Coordinates: 2050294..2051337 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain KG-18
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2045294..2056337

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GDK18_RS10245 (SAKG18_18750)	-	2045715..2046971 (-)	1257	WP_001795108.1	aminopeptidase	-
GDK18_RS10250 (SAKG18_18760)	-	2046974..2047174 (-)	201	WP_000180460.1	DUF1128 family protein	-
GDK18_RS10255 (SAKG18_18770)	-	2047321..2047785 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
GDK18_RS10260 (SAKG18_18780)	-	2047792..2048067 (+)	276	WP_117195002.1	YtxH domain-containing protein	-
GDK18_RS10265 (SAKG18_18790)	-	2048345..2049562 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
GDK18_RS10270 (SAKG18_18800)	vraR	2049675..2050304 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
GDK18_RS10275 (SAKG18_18810)	vraS	2050294..2051337 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
GDK18_RS10280 (SAKG18_18820)	liaF	2051334..2052035 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
GDK18_RS10285 (SAKG18_18830)	-	2052050..2052436 (-)	387	WP_001110179.1	hypothetical protein	-
GDK18_RS10290 (SAKG18_18840)	map	2052653..2053411 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
GDK18_RS10295 (SAKG18_18850)	-	2053942..2054928 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
GDK18_RS10300 (SAKG18_18860)	-	2055359..2055772 (-)	414	WP_001557448.1	hypothetical protein	-
GDK18_RS10305	-	2055801..2055911 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=72788 GDK18_RS10275 WP_001017131.1 2050294..2051337(-) (vraS) [Staphylococcus aureus strain KG-18]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=72788 GDK18_RS10275 WP_001017131.1 2050294..2051337(-) (vraS) [Staphylococcus aureus strain KG-18]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1