Detailed information NTG0726153

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NYR13_RS05170
• Genome accession: NZ_CP103860
• Coordinates: 1015353..1016396 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain R3-8
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1010353..1021396

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYR13_RS05140 (NYR13_05140)	-	1010664..1010774 (+)	111	WP_001790257.1	hypothetical protein	-
NYR13_RS05145 (NYR13_05145)	-	1010803..1011216 (+)	414	WP_001549145.1	hypothetical protein	-
NYR13_RS05150 (NYR13_05150)	-	1011765..1012751 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
NYR13_RS05155 (NYR13_05155)	map	1013279..1014037 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NYR13_RS05160 (NYR13_05160)	-	1014254..1014640 (+)	387	WP_001110179.1	hypothetical protein	-
NYR13_RS05165 (NYR13_05165)	liaF	1014655..1015356 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NYR13_RS05170 (NYR13_05170)	vraS	1015353..1016396 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NYR13_RS05175 (NYR13_05175)	vraR	1016386..1017015 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NYR13_RS05180 (NYR13_05180)	-	1017131..1018348 (-)	1218	WP_251354267.1	YihY/virulence factor BrkB family protein	-
NYR13_RS05185 (NYR13_05185)	-	1018626..1018901 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
NYR13_RS05190 (NYR13_05190)	-	1018908..1019372 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NYR13_RS05195 (NYR13_05195)	-	1019519..1019719 (+)	201	WP_000180461.1	DUF1128 family protein	-
NYR13_RS05200 (NYR13_05200)	-	1019722..1020978 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=726153 NYR13_RS05170 WP_001017131.1 1015353..1016396(+) (vraS) [Staphylococcus aureus strain R3-8]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=726153 NYR13_RS05170 WP_001017131.1 1015353..1016396(+) (vraS) [Staphylococcus aureus strain R3-8]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1