Detailed information NTG0725998

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NYF25_RS09675
• Genome accession: NZ_CP103850
• Coordinates: 1969230..1970273 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NRL 02/947
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1964230..1975273

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYF25_RS09645 (NYF25_09645)	-	1964648..1965904 (-)	1257	WP_001795438.1	aminopeptidase	-
NYF25_RS09650 (NYF25_09650)	-	1965907..1966107 (-)	201	WP_000180461.1	DUF1128 family protein	-
NYF25_RS09655 (NYF25_09655)	-	1966254..1966718 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NYF25_RS09660 (NYF25_09660)	-	1966725..1967000 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NYF25_RS09665 (NYF25_09665)	-	1967278..1968495 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
NYF25_RS09670 (NYF25_09670)	vraR	1968611..1969240 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NYF25_RS09675 (NYF25_09675)	vraS	1969230..1970273 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NYF25_RS09680 (NYF25_09680)	liaF	1970270..1970971 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NYF25_RS09685 (NYF25_09685)	-	1970986..1971372 (-)	387	WP_001110179.1	hypothetical protein	-
NYF25_RS09690 (NYF25_09690)	map	1971589..1972347 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NYF25_RS09695 (NYF25_09695)	-	1972934..1973920 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
NYF25_RS09700 (NYF25_09700)	-	1974410..1974823 (-)	414	WP_001549145.1	hypothetical protein	-
NYF25_RS09705 (NYF25_09705)	-	1974852..1974962 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=725998 NYF25_RS09675 WP_001017131.1 1969230..1970273(-) (vraS) [Staphylococcus aureus strain NRL 02/947]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=725998 NYF25_RS09675 WP_001017131.1 1969230..1970273(-) (vraS) [Staphylococcus aureus strain NRL 02/947]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1