Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   PVK49_RS02620 Genome accession   NZ_CP118306
Coordinates   514024..514665 (+) Length   213 a.a.
NCBI ID   WP_047235722.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 20154608     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 509024..519665
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PVK49_RS02600 (PVK49_02595) - 509571..510311 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  PVK49_RS02605 (PVK49_02600) pknB 510308..512215 (+) 1908 WP_047235721.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  PVK49_RS02610 (PVK49_02605) liaF 512338..513030 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  PVK49_RS02615 (PVK49_02610) - 513027..514031 (+) 1005 WP_002991890.1 sensor histidine kinase -
  PVK49_RS02620 (PVK49_02615) vraR 514024..514665 (+) 642 WP_047235722.1 response regulator transcription factor Regulator
  PVK49_RS02625 (PVK49_02620) - 514702..516102 (+) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  PVK49_RS02630 (PVK49_02625) - 516102..516479 (+) 378 WP_009880466.1 S1 RNA-binding domain-containing protein -
  PVK49_RS02635 (PVK49_02630) cysK 516497..517438 (-) 942 WP_373939365.1 cysteine synthase A -
  PVK49_RS02640 (PVK49_02635) - 517566..518198 (-) 633 WP_009880468.1 YigZ family protein -
  PVK49_RS02645 (PVK49_02640) comFA/cflA 518254..519579 (+) 1326 WP_047235723.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23785.45 Da        Isoelectric Point: 5.1641

>NTDB_id=721631 PVK49_RS02620 WP_047235722.1 514024..514665(+) (vraR) [Streptococcus pyogenes strain 20154608]
MSKIKVILVDDHEMVRMGLKSFLNFQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=721631 PVK49_RS02620 WP_047235722.1 514024..514665(+) (vraR) [Streptococcus pyogenes strain 20154608]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTTCAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTAGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCCATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.726

100

0.39