Detailed information NTG0072122

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL334_RS02715
• Genome accession: NZ_AP019192
• Coordinates: 500637..501374 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain ASP0581
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 495637..506374

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL334_RS02675	-	496612..496806 (-)	195	WP_001808905.1	hypothetical protein	-
EL334_RS02680 (ASP0581_04980)	-	496968..497255 (-)	288	WP_000777753.1	hypothetical protein	-
EL334_RS02685 (ASP0581_04990)	-	497265..497675 (-)	411	WP_033705511.1	HIT family protein	-
EL334_RS02690 (ASP0581_05000)	pptA	497743..498474 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
EL334_RS02695 (ASP0581_05010)	-	498471..499520 (+)	1050	WP_000653771.1	ABC transporter permease	-
EL334_RS02705 (ASP0581_05020)	-	499688..500017 (-)	330	WP_000132572.1	hypothetical protein	-
EL334_RS02710 (ASP0581_05030)	-	500294..500632 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
EL334_RS02715 (ASP0581_05040)	comE/blpR	500637..501374 (+)	738	WP_001219122.1	response regulator transcription factor	Regulator
EL334_RS02720 (ASP0581_05050)	-	501387..502727 (+)	1341	WP_000275285.1	sensor histidine kinase	-
EL334_RS02725 (ASP0581_05060)	blpC	502772..502927 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
EL334_RS02730 (ASP0581_05070)	-	502984..504345 (-)	1362	WP_033705510.1	bacteriocin secretion accessory protein	-
EL334_RS02735 (ASP0581_05080)	comA/nlmT	504356..506032 (-)	1677	WP_332066666.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=72122 EL334_RS02715 WP_001219122.1 500637..501374(+) (comE/blpR) [Streptococcus pneumoniae strain ASP0581]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=72122 EL334_RS02715 WP_001219122.1 500637..501374(+) (comE/blpR) [Streptococcus pneumoniae strain ASP0581]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38