Detailed information NTG0720680

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW941_RS09770
• Genome accession: NZ_CP102963
• Coordinates: 1981328..1982371 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 40-B-50
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1976328..1987371

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW941_RS09740 (NW941_09775)	-	1976749..1978005 (-)	1257	WP_001793428.1	aminopeptidase	-
NW941_RS09745 (NW941_09780)	-	1978008..1978208 (-)	201	WP_000180460.1	DUF1128 family protein	-
NW941_RS09750 (NW941_09785)	-	1978355..1978819 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NW941_RS09755 (NW941_09790)	-	1978826..1979101 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NW941_RS09760 (NW941_09795)	-	1979379..1980596 (+)	1218	WP_045158466.1	YihY/virulence factor BrkB family protein	-
NW941_RS09765 (NW941_09800)	vraR	1980709..1981338 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NW941_RS09770 (NW941_09805)	vraS	1981328..1982371 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW941_RS09775 (NW941_09810)	liaF	1982368..1983069 (-)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
NW941_RS09780 (NW941_09815)	-	1983084..1983470 (-)	387	WP_001110179.1	hypothetical protein	-
NW941_RS09785 (NW941_09820)	map	1983687..1984445 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NW941_RS09790 (NW941_09825)	-	1984972..1985958 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
NW941_RS09795 (NW941_09830)	-	1986147..1986560 (-)	414	WP_258412606.1	hypothetical protein	-
NW941_RS09800 (NW941_09835)	-	1986589..1986697 (-)	109	Protein_1890	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720680 NW941_RS09770 WP_001017131.1 1981328..1982371(-) (vraS) [Staphylococcus aureus strain 40-B-50]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720680 NW941_RS09770 WP_001017131.1 1981328..1982371(-) (vraS) [Staphylococcus aureus strain 40-B-50]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1