Detailed information NTG0720639

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW971_RS10065
• Genome accession: NZ_CP102962
• Coordinates: 2019245..2020288 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 16CS0212
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2014245..2025288

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW971_RS10035 (NW971_10035)	-	2014666..2015922 (-)	1257	WP_258464381.1	aminopeptidase	-
NW971_RS10040 (NW971_10040)	-	2015925..2016125 (-)	201	WP_258464985.1	DUF1128 family protein	-
NW971_RS10045 (NW971_10045)	-	2016272..2016736 (+)	465	WP_258464382.1	low molecular weight protein-tyrosine-phosphatase	-
NW971_RS10050 (NW971_10050)	-	2016743..2017018 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NW971_RS10055 (NW971_10055)	-	2017296..2018513 (+)	1218	WP_258464383.1	YihY/virulence factor BrkB family protein	-
NW971_RS10060 (NW971_10060)	vraR	2018626..2019255 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NW971_RS10065 (NW971_10065)	vraS	2019245..2020288 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW971_RS10070 (NW971_10070)	liaF	2020285..2020986 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NW971_RS10075 (NW971_10075)	-	2021001..2021387 (-)	387	WP_001110179.1	hypothetical protein	-
NW971_RS10080 (NW971_10080)	map	2021603..2022361 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NW971_RS10085 (NW971_10085)	-	2022946..2023932 (+)	987	WP_258464384.1	aromatic acid exporter family protein	-
NW971_RS10090 (NW971_10090)	-	2024420..2024833 (-)	414	WP_111762822.1	hypothetical protein	-
NW971_RS10095 (NW971_10095)	-	2024862..2024972 (-)	111	WP_111762470.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720639 NW971_RS10065 WP_001017131.1 2019245..2020288(-) (vraS) [Staphylococcus aureus strain 16CS0212]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720639 NW971_RS10065 WP_001017131.1 2019245..2020288(-) (vraS) [Staphylococcus aureus strain 16CS0212]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTGGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1