Detailed information NTG0720225

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW967_RS09250
• Genome accession: NZ_CP102952
• Coordinates: 1919367..1920410 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 39-B-49
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1914367..1925410

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW967_RS09220 (NW967_09220)	-	1914785..1916041 (-)	1257	WP_001793428.1	aminopeptidase	-
NW967_RS09225 (NW967_09225)	-	1916044..1916244 (-)	201	WP_000180460.1	DUF1128 family protein	-
NW967_RS09230 (NW967_09230)	-	1916391..1916855 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NW967_RS09235 (NW967_09235)	-	1916862..1917137 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NW967_RS09240 (NW967_09240)	-	1917415..1918632 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
NW967_RS09245 (NW967_09245)	vraR	1918748..1919377 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NW967_RS09250 (NW967_09250)	vraS	1919367..1920410 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW967_RS09255 (NW967_09255)	liaF	1920407..1921108 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NW967_RS09260 (NW967_09260)	-	1921123..1921509 (-)	387	WP_001110179.1	hypothetical protein	-
NW967_RS09265 (NW967_09265)	map	1921726..1922484 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
NW967_RS09270 (NW967_09270)	-	1922900..1923886 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
NW967_RS09275 (NW967_09275)	-	1924075..1924488 (-)	414	Protein_1787	hypothetical protein	-
NW967_RS09280 (NW967_09280)	-	1924517..1924625 (-)	109	Protein_1788	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720225 NW967_RS09250 WP_001017131.1 1919367..1920410(-) (vraS) [Staphylococcus aureus strain 39-B-49]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720225 NW967_RS09250 WP_001017131.1 1919367..1920410(-) (vraS) [Staphylococcus aureus strain 39-B-49]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1