Detailed information NTG0071968

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EL263_RS09625
• Genome accession: NZ_AP018938
• Coordinates: 1797832..1798869 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain ATCC 49619
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1792832..1803869

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL263_RS09600 (SPAT_1821)	-	1793571..1794902 (-)	1332	WP_000390039.1	hemolysin family protein	-
EL263_RS09605 (SPAT_1822)	endA	1795193..1796017 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
EL263_RS09610 (SPAT_1823)	-	1796056..1796244 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EL263_RS09615 (SPAT_1824)	murA	1796237..1797520 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EL263_RS09620 (SPAT_1825)	-	1797544..1797774 (-)	231	WP_000250393.1	DUF1146 family protein	-
EL263_RS09625 (SPAT_1826)	sepM	1797832..1798869 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EL263_RS09630 (SPAT_1827)	coaD	1798853..1799341 (-)	489	WP_050221168.1	pantetheine-phosphate adenylyltransferase	-
EL263_RS09635 (SPAT_1828)	rsmD	1799331..1799870 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EL263_RS09640 (SPAT_1829)	asnA	1799935..1800927 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EL263_RS09650 (SPAT_1830)	-	1801039..1801722 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EL263_RS09655 (SPAT_1831)	-	1801778..1802518 (-)	741	WP_000152692.1	TrmH family RNA methyltransferase	-
EL263_RS09660 (SPAT_1832)	-	1802552..1802830 (+)	279	WP_001174613.1	acylphosphatase	-
EL263_RS09665 (SPAT_1833)	yidC	1802908..1803834 (+)	927	WP_000835949.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=71968 EL263_RS09625 WP_000727277.1 1797832..1798869(-) (sepM) [Streptococcus pneumoniae strain ATCC 49619]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=71968 EL263_RS09625 WP_000727277.1 1797832..1798869(-) (sepM) [Streptococcus pneumoniae strain ATCC 49619]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAATTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591