Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   EL277_RS04105 Genome accession   NZ_AP018936
Coordinates   775451..777709 (-) Length   752 a.a.
NCBI ID   WP_000882523.1    Uniprot ID   A0A4J1WRX6
Organism   Streptococcus pneumoniae strain NU83127     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 770451..782709
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL277_RS04070 - 770497..771399 (+) 903 Protein_772 IS630 family transposase -
  EL277_RS04075 (SPNU_0767) tnpB 771422..771772 (-) 351 WP_000586654.1 IS66 family insertion sequence element accessory protein TnpB -
  EL277_RS04080 (SPNU_0769) - 772014..773285 (+) 1272 Protein_774 IS3 family transposase -
  EL277_RS04085 (SPNU_0770) - 773394..773693 (-) 300 WP_000767193.1 DUF1827 family protein -
  EL277_RS04095 (SPNU_0771) - 773858..774280 (-) 423 WP_001849729.1 NUDIX hydrolase -
  EL277_RS04100 - 774391..775244 (+) 854 Protein_777 IS630 family transposase -
  EL277_RS04105 (SPNU_0774) clpE 775451..777709 (-) 2259 WP_000882523.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  EL277_RS04110 (SPNU_0775) - 777938..778168 (-) 231 WP_000443573.1 YkuJ family protein -
  EL277_RS04115 (SPNU_0776) - 778533..779486 (+) 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
  EL277_RS04120 (SPNU_0777) - 779603..780286 (+) 684 WP_001011637.1 amino acid ABC transporter permease -
  EL277_RS04125 (SPNU_0778) - 780286..781020 (+) 735 WP_000140951.1 amino acid ABC transporter ATP-binding protein -
  EL277_RS04130 (SPNU_0779) - 781199..782056 (+) 858 WP_000192090.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83814.18 Da        Isoelectric Point: 5.3713

>NTDB_id=71785 EL277_RS04105 WP_000882523.1 775451..777709(-) (clpE) [Streptococcus pneumoniae strain NU83127]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPSISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=71785 EL277_RS04105 WP_000882523.1 775451..777709(-) (clpE) [Streptococcus pneumoniae strain NU83127]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGACGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACAGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTAGCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GTCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCTCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGATAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAGCTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterProScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA lid domain (AAA_lid_9)

(293-390)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae TIGR4

100

100

1
  clpE Streptococcus pneumoniae Rx1

99.867

100

0.999
  clpE Streptococcus pneumoniae D39

99.867

100

0.999
  clpE Streptococcus pneumoniae R6

99.867

100

0.999
  clpE Streptococcus mutans UA159

82.731

99.335

0.822
  clpC Lactococcus lactis subsp. cremoris KW2

76.839

97.606

0.75
  clpC Bacillus subtilis subsp. subtilis str. 168

52.308

86.436

0.452
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus mutans UA159

47.36

83.112

0.394
  clpC Streptococcus thermophilus LMD-9

46.88

83.112

0.39
  clpC Streptococcus thermophilus LMG 18311

46.486

83.245

0.387

Multiple sequence alignment